Trial · NCT06680869
Early Amiodarone in Shockable Cardiac Arrest
NCT06680869, Phase 3, Recruiting, Oregon Health and Science University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Early Amiodarone in Shockable Cardiac Arrest. Trials, record NCT06680869. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06680869
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Early Amiodarone in Shockable Cardiac Arrest
- NCT number
- NCT06680869
- Status
- Recruiting
- Phases
- Phase 3
- Enrollment
- 585 participants, estimated
- Lead sponsor
- Oregon Health and Science University
- Conditions
- Cardiac Arrest
- Interventions
- Amiodarone Hydrochloride Injection, Usual Care Protocol
- First posted
- 2024-11-08
- Last updated
- 2025-12-19
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Time from emergency medical services (EMS) arrival on-scene (or time of arrest if witnessed by EMS) to the administration of the initial dose of amiodarone in minutes | up to 1 day | |
| Secondary | The number and proportion of patients receiving the initial dose of amiodarone from emergency medical services before the third shock from a defibrillator | up to 1 day | |
| Secondary | The number and proportion of patients with pulses present and documented by emergency medical services at the time of patient care transfer to hospital staff at emergency department arrival | up to 1 day | |
| Secondary | The number and proportion of patients surviving to be admitted to inpatient services after arrival to the emergency department | up to 1 day | |
| Secondary | The number and proportion of patients surviving to be discharged from the hospital (or 30 days, whichever is sooner) after their admission for cardiac arrest | up to 30 days | |
| Secondary | The number and proportion of patients surviving to be discharged from the hospital (or 30 days, whichever is sooner) after their admission for cardiac arrest with a Cerebral Performance Category score of 1 or 2 | up to 30 days | The Cerebral Performance Category (CPC) score scale is 1-5: CPC 1: Good cerebral performance: conscious, alert, able to work, might have mild neurologic or psychologic deficit. CPC 2: Moderate cerebral disability: conscious, sufficient cerebral function for independent activities of daily life. Able to work in sheltered environment. CPC 3: Severe cerebral disability: conscious, dependent on others for daily support because of impaired brain function. Ranges from ambulatory state to severe dementia or paralysis. CPC 4: Coma or vegetative state: any degree of coma without the presence of all brain death criteria. Unawareness, even if appears awake (vegetative state) without interaction with environment; may have spontaneous eye opening and sleep/awake cycles. Cerebral unresponsiveness. CPC 5: Brain death: apnea, areflexia, EEG silence, etc. |
| Secondary | Time from emergency medical services (EMS) arrival on-scene (or time of arrest if witnessed by EMS) to the delivery of other critical interventions in minutes | up to 1 day | Critical interventions include: the second-fourth defibrillator shocks, the first use of double sequential external defibrillation, the administration of the first two epinephrine doses, and the time to advanced airway placement by EMS. |
| Secondary | Number and proportion of participants with adverse events | up to 1 day | e.g.: malignant cardiac arrhythmia, allergic reaction, recurrent cardiac arrest |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| K23HL173647 | Optimizing the Timing and Route of Antiarrhythmic Administration in Out-of-Hospital Cardiac Arrest | LUPTON, JOSHUA | OREGON HEALTH & SCIENCE UNIVERSITY | NATIONAL HEART, LUNG, AND BLOOD INSTITUTE | 2024 to 2025 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06680869
GET https://conductscience.org/api/trials/v1/NCT06680869/registered