Trial · NCT06726200
A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid Use
NCT06726200, Early phase 1, Recruiting, Rachel R. Luba
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid Use. Trials, record NCT06726200. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06726200
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid Use
- NCT number
- NCT06726200
- Status
- Recruiting
- Phases
- Early phase 1
- Enrollment
- 60 participants, estimated
- Lead sponsor
- Rachel R. Luba
- Conditions
- Opioid Use Disorder
- Interventions
- Buprenorphine + naloxone (Suboxone), Buprenorphine Injection
- First posted
- 2024-12-10
- Last updated
- 2026-06-02
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Percentage of Days Abstinent from Opioids | 4 week follow up period | Abstinence from Opioids (% days abstinent; continuous; longitudinal) during each week of the 4 week follow up period measured via the timeline follow back. |
| Primary | Sustained Relapse | 4 week follow up period | Sustained relapse during the 4 week follow up period (binary), defined as 5 consecutive days of illicit opioid use reported on the timeline follow back at any point during the 4 week follow up period. |
| Secondary | Time to Peak Clinical Opiate Withdrawal Scale (COWS) score | During the inpatient induction period (approximately 1 overnight stay) | The time to peak Clinical Opiate Withdrawal Scale (COWS) score during the induction period (time-to-event/survival). The COWS ranges from 0-48 with higher scores indicating more severe opioid withdrawal symptoms. |
| Secondary | Peak Clinical Opiate Withdrawal Scale (COWS) score | During the inpatient induction period (approximately 1 overnight stay) | The peak Clinical Opiate Withdrawal Scale (COWS) score during the induction period (continuous). The COWS ranges from 0-48 with higher scores indicating more severe opioid withdrawal symptoms. |
| Secondary | Dropout during induction | During the inpatient induction period (approximately 1 overnight stay) | Dropout during the induction period (binary) |
| Other | Exploratory Outcome 1: Craving | Induction Period (Overnight Inpatient Stay) and 4-week follow up period | Craving as reported on the Opioid Craving Visual Analog Scale OC-VAS (longitudinal; continuous) during induction and follow up. The OC-VAS ranges from 0-100mm with higher ratings indicating more intense/severe craving. |
| Other | Exploratory Outcome 2: Clinical Opiate Withdrawal Scale (COWS) Score | Induction Period (Overnight Inpatient Stay) and 4-week follow up period | Opioid Withdrawal Symptoms as reported on the Clinical Opiate Withdrawal Scale (COWS; longitudinal; continuous) during induction and follow up. The COWS ranges from 0-48 with higher scores indicating more severe opioid withdrawal symptoms. |
| Other | Exploratory Outcome 3: Time to first use of illicit opioids | 4-week follow up period | Time to first use of illicit opioids during the 4-week follow up period (time-to-event/survival) |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| K23DA057392 | A Randomized Controlled Trial Examining Extended-Injectable Buprenorphine in those who use High Potency Synthetic Opioids | LUBA, RACHEL R | COLUMBIA UNIVERSITY HEALTH SCIENCES | NATIONAL INSTITUTE ON DRUG ABUSE | 2024 to 2025 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06726200
GET https://conductscience.org/api/trials/v1/NCT06726200/registered