Trial · NCT06784349
ALN-APOC3 in Adult Participants With Dyslipidemia
NCT06784349, Phase 1, Completed, Regeneron Pharmaceuticals
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. ALN-APOC3 in Adult Participants With Dyslipidemia. Trials, record NCT06784349. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06784349
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- ALN-APOC3 in Adult Participants With Dyslipidemia
- NCT number
- NCT06784349
- Status
- Completed
- Phases
- Phase 1
- Enrollment
- 32 participants, actual
- Lead sponsor
- Regeneron Pharmaceuticals
- Conditions
- Dyslipidemia
- Interventions
- ALN-APOC3, Matching Placebo
- First posted
- 2025-01-20
- Last updated
- 2026-03-16
Source ClinicalTrials.gov
Registered outcomes28
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Incidence of Treatment Emergent Adverse Events (TEAEs) | Through Week 44 | |
| Primary | Severity of TEAEs | Through Week 44 | |
| Primary | Percent changes in fasting concentrations of High-Density Lipoprotein Cholesterol (HDL-C) | Baseline to week 24 | Part B Only |
| Secondary | Concentration of combined ALN-APOC3 and metabolites in plasma | Through Week 44 | |
| Secondary | Urinary excretion of combined ALN-APOC3 and metabolites | Through 24 Hours, After Treatment | Part A Only |
| Secondary | Percent change in fasting concentrations of APOC3 | Baseline to Week 12 | |
| Secondary | Absolute change in fasting concentrations of APOC3 | Baseline to Week 12 | |
| Secondary | Percent change in fasting concentrations of APOC3 | Baseline to Week 24 | Part B Only |
| Secondary | Absolute change in fasting concentrations of APOC3 | Baseline to Week 24 | Part B Only |
| Secondary | Percent change in fasting concentrations of HDL-C | Baseline to Week 12 |
1 to 10 of 28Source ClinicalTrials.gov
See all 28 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06784349
GET https://conductscience.org/api/trials/v1/NCT06784349/registered?page=2