Trial · NCT06785272
Magnesium Trial in Acute Asthma in Emergency Department
NCT06785272, Phase 3, Recruiting, Suzanne Schuh
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Magnesium Trial in Acute Asthma in Emergency Department. Trials, record NCT06785272. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06785272
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Magnesium Trial in Acute Asthma in Emergency Department
- NCT number
- NCT06785272
- Status
- Recruiting
- Phases
- Phase 3
- Enrollment
- 192 participants, estimated
- Lead sponsor
- Suzanne Schuh
- Conditions
- Asthma
- Interventions
- magnesium sulfate, Normal Saline
- First posted
- 2025-01-21
- Last updated
- 2025-12-18
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Pediatric Respiratory Assessment Measure (PRAM) score: This score ranges from 0-12. A score from 0-3 is mild, 4-7 moderate and 8-12 severe. A low score is a better outcome and a high score is a worse outcome. | The primary outcome measure will be the PRAM score at 120 minutes post start of experimental therapy. | PRAM is a validated 12-point asthma severity score which exhibits the most comprehensive measurement properties of all asthma scores and has been successfully used as an outcome in major trials. It is the only score with demonstrated criterion validity, using respiratory resistance as the gold standard. PRAM has been validated in both preschool and school-aged children in the ED with asthma and has strong association with admission. PRAM has inter-rater reliability above 70% and is adopted in all pediatric EDs in Canada. Most children treated for acute asthma are preschoolers who lack coordination to perform pulmonary function tests reliably. To maximize the accuracy of the PRAM measurement, all study nurses will complete an online PRAM training module. We will use an eligibility cut-off of PRAM ≥ 5 post initial therapy as this is associated with clinically concerning respiratory distress requiring further intervention. A PRAM score from 0-3 is mild, 4-7 moderate and 8-12 severe. |
| Secondary | Changes in PRAM score | Changes in PRAM score from baseline (pre intervention) to 30, 60, 120, 180 minutes after start of experimental therapy | Changes in vital signs |
| Secondary | Hospitalization for asthma at the index ED visit | Up to 24 hours after starting experimental therapy | Defined as admission to an inpatient unit due to continued/worsening distress |
| Secondary | Changes in respiratory rate | From baseline (pre-intervention) to 30,60,120 and 180 minutes post intervention (respiratory rate ) | Changes in vital signs |
| Secondary | Changes in oxygen saturation | From baseline (pre-intervention) to 30,60,120 and 180 minutes post intervention ( oxygen saturation) | Changes in vital signs |
| Secondary | Changes in blood pressure | From baseline (pre-intervention) to 10,20,30,60,120, and 180 minutes post intervention (blood pressure). | Changes in vital signs |
| Secondary | PRAM denoting mild asthma (≤ 3 points is a widely accepted discharge criterion). | at 120 minutes post intervention | Pediatric Respiratory Assessment Measure (PRAM) is a valid clinical score assessing acute asthma severity in toddlers and teenages. Score ranges from 0 to 12 (mild to severe). A higher score is a more severe asthma measurement. A low score is a better outcome than a high score. |
| Secondary | Hospitalization for asthma at any medical facility | within 72 hours post- ED discharge | Defined as admission to an inpatient unit due to continued/worsening distress |
| Secondary | Unscheduled asthma-related visits to any health care provider | within 72 hours post- ED discharge | Family-initiated asthma-related medical visit |
| Secondary | Hospital length of stay. | From presentation at the Emergency Department triage to the time of hospital discharge, up to 4 weeks. | Length of stay is the duration of a hospital stay in hours |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06785272
GET https://conductscience.org/api/trials/v1/NCT06785272/registered