Trial · NCT06807892
Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients
NCT06807892, Not applicable, Recruiting, University Hospital, Angers
3 sourcestrials-2026-11-12-0.4.0
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ConductScience Library. Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients. Trials, record NCT06807892. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06807892
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Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients
- NCT number
- NCT06807892
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 40 participants, estimated
- Lead sponsor
- University Hospital, Angers
- Conditions
- Huntington's Disease (HD), Exergame
- Interventions
- Synergistic management, Sequential management
- First posted
- 2025-02-04
- Last updated
- 2026-03-17
Source ClinicalTrials.gov
Registered outcomes15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Berg Balance Scale (BBS) | Sessions are held three times a week for 12 weeks. | The BBS is a scale comprising 14 tests designed to assess static and dynamic balance. Each test is given a score ranging from 0 (inability to perform the test) to 4 (no difficulty in performing the test), giving a final score out of 56 points (the higher the score, the better the balance skills). The tests included in the BBS are: * Sitting * Standing without support * Standing with feet together * Standing with eyes closed * From sitting to standing * Move from standing to sitting * Transfer between two chairs * Standing in tandem * Stand on one leg * Alternating feet on a step or stair while standing * Rotate trunk * Turn around to look over shoulders * Forward movement with arms outstretched * Picking up an object from the ground |
| Secondary | L'Unified Huntington's Disease Rating Scale - Total Motor Score (UHDRS-TMS) | baseline - Day 90- Day 180 | The UHDRS is the conventional scale for studying the progression of MH symptomatology. It is divided into several subscales grouping together different tests: motor function (vision, dysarthria, dystonia, choreic movements, bradykinesia, walking, etc.), cognitive functions (verbal fluency, Symbol Digit Modalities test, Stroop task, TMT, Digit Memory (WAIS-IV), behavior, functional abilities, independence. For the motor function and behavior subscales, the results are a score, and the higher the score, the greater the motor and behavioral disorders. Conversely, for the cognitive, functional and independence subscales, the higher the score, the stronger the cognitive and functional abilities, and the greater the patient's subjective independence. The UHDRS motor tests are scored from 0 (no impairment) to 4 (severe impairment), giving a total score out of 60 points. The closer the score to 60, the greater the motor impairment. |
| Secondary | Six-Minute Walk Test (6MWT) | baseline - Day 90- Day 180 | The 6MWT consists in measuring the distance (in meters) covered in 6 minutes by the participant. It is therefore a recommended tool for measuring walking endurance in MH patients. A straight, flat corridor measuring between 20 and 50 metres is marked out with coloured markers and two cones at either end. The patient is asked to walk as far as possible for 6 minutes, back and forth along the corridor. During the test, the patient can slow down and even stop if necessary, but is obliged to go around the cones at each half-turn. At the end of the 6 minutes, the patient must stop and not move until the distance covered is measured. The longer the total distance covered, the greater the walking endurance. |
| Secondary | 30 second Chair Stand Test (30CST) | baseline - Day 90- Day 180 | The 30CST consists of standing up and sitting down from a chair as many times as possible for thirty seconds, without physical assistance. The greater the number of repetitions, the greater the muscular strength of the lower limbs. |
| Secondary | Mini Mental State Examination (MMSE) | baseline - Day 90- Day 180 | The MMSE enables us to assess global cognitive functioning on a 30-point scale. It comprises 6 subsections: orientation, learning, attention and calculation, recall, language and constructive praxis, scored out of 10, 3, 5, 3, 8 and 1 respectively. The test takes 10 minutes to complete. The higher the score, the better the performance. A score between 22 and 25 suggests mild dementia, between 16 and 20 moderate dementia, between 10 and 15 moderately severe dementia, between 3 and 9 severe dementia and finally very severe dementia below 3. It will be used in this study to check inclusion criteria and assess the patient's overall cognitive abilities. |
| Secondary | The working memory subtest of the Wechsler Intelligence Scale for Adults 4th Edition (WAIS-IV, subtest "Number Memory") | baseline - Day 90- Day 180 | The WAIS IV "Digit Memory" sub-test is frequently used in neuropsychological practice to assess auditory attention and auditory working memory. The assessment is carried out in three stages. First, the patient is asked to repeat the digits dictated orally by the evaluator. The exercise starts with 2 digits, and increases after at least one successful attempt out of two. The principle is the same for the next exercise, during which the subject must repeat the sequence of digits in the reverse order to that dictated. For the last exercise, the subject must reconstruct the sequence of numbers in ascending order. Each attempt is marked 0 or 1. The total score is then calculated. |
| Secondary | UHDRS cognitive tests - The Stroop test | baseline - Day 90- Day 180 | The Stroop test assesses inhibition. Three boards are presented: the first consists of naming colored rectangles (blue, green or red) and the second of naming words written in letters (blue, green or red). On the third board, the words designating the colors are printed in ink of a different color from that designated. The subject must inhibit reading the word in order to name the ink color. |
| Secondary | UHDRS cognitive tests - The Symbol Digit Modalities Test (SDMT) | baseline - Day 90- Day 180 | During the SDMT, which assesses patients' psychomotor speed and working memory, the numbers from 1 to 9 are each associated with a specific symbol on a model. The participant must assign the numbers to the symbols presented line by line. The aim is to correctly associate as many numbers as possible with the different symbols within 90 seconds. The support is written and the model remains in front of the patient for the duration of the test. |
| Secondary | UHDRS cognitive tests - Verbal fluency task | baseline - Day 90- Day 180 | The verbal fluency task assessing mental flexibility is composed of two tests: semantic fluency and phonological fluency. In the semantic fluency test, the patient is asked to generate as many words as possible in 1 minute from a category (e.g. fruit, animals, etc.). In the phonological fluency test, the patient is asked to generate a maximum number of words in 1 minute from a letter (e.g. P, R or V). |
| Secondary | UHDRS cognitive tests - The Trail Making Test (TMT) | baseline - Day 90- Day 180 | The Trail Making Test is a paper-and-pencil test that assesses spontaneous flexibility. It is offered in two parts. In part A, the subject is asked to connect numbers from 1 to 25 as quickly as possible. For part B, the subject is asked to connect numbers and letters, alternating the number/letter sequence and maintaining ascending numbering and alphabetical order. All stimuli are presented and two examples are performed before each part. Time and errors are recorded. |
1 to 10 of 15Source ClinicalTrials.gov
See all 15 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests6
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Category Fluency | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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