Project Gnosis: the Neurophysical and Psychosocial Health Outcomes of Tai Chi for Older Adults with Cognitive Concerns or Mild Cognitive Impairment
NCT06828926, Not applicable, Recruiting, Ohio University
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Project Gnosis: the Neurophysical and Psychosocial Health Outcomes of Tai Chi for Older Adults with Cognitive Concerns or Mild Cognitive Impairment | ClinicalTrials.gov |
| NCT number | NCT06828926 | ClinicalTrials.gov |
| Status | Recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 50 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Ohio University | ClinicalTrials.gov |
| Conditions | Mild Cognitive Impairment (MCI), Sarcopenia | ClinicalTrials.gov |
| Interventions | Tai Chi | ClinicalTrials.gov |
| First posted | 2025-02-17 | ClinicalTrials.gov |
| Last updated | 2025-02-17 | ClinicalTrials.gov |
Registered outcomes 17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Executive Function - Stroop Color-Word Interference Test | From enrollment to the end of treatment at 8 weeks | Delis-Kaplan Executive Function System Stroop Color-Word Interference Test | ClinicalTrials.gov |
| Primary | Executive Function - Semantic Fluency Test | From enrollment to the end of treatment at 8 weeks | Repeatable Battery for the Assessment of Neuropsychological Status - Semantic Fluency Test | ClinicalTrials.gov |
| Secondary | Cognitive Function - Processing Speed | From enrollment to the end of treatment at 8 weeks | Repeatable Battery for the Assessment of Neuropsychological Status Coding Test | ClinicalTrials.gov |
| Secondary | Pain Interference | From enrollment to the end of treatment at 8 weeks | Patient Reported Outcome Measurement Information System (PROMIS) - Pain Interference Item Bank | ClinicalTrials.gov |
| Secondary | Social Isolation | From enrollment to the end of treatment at 8 weeks | Patient Reported Outcome Measurement Information System (PROMIS) Social Isolation Item Bank | ClinicalTrials.gov |
| Secondary | Positive Affect | From enrollment to the end of treatment at 8 weeks | Patient Reported Outcome Measurement Information System (PROMIS) Positive Affect Item Bank | ClinicalTrials.gov |
| Secondary | Meaning and Purpose | From enrollment to the end of treatment at 8 weeks | Patient Reported Outcome Measurement Information System (PROMIS) Meaning and Purpose Item bank | ClinicalTrials.gov |
| Secondary | Heart Rate Variability | From enrollment to the end of treatment at 8 weeks | Heart Rate Variability recorded while sitting for 5 minutes using a photoplethysmogram. | ClinicalTrials.gov |
| Secondary | Cortical activity | From enrollment to the end of treatment at 8 weeks | Cortical activity will be recorded during a brief Tai Chi Practice before and after the 8-week Tai Chi intervention using a functional Near Infrared Spectroscopy system. | ClinicalTrials.gov |
| Other | Cognitive Assessment Screen | From enrollment only | Montreal Cognitive Assessment used as a screening tool which measures short term memory, visuospatial abilities, executive functions, attention, concentration and working memory, and language orientation to time and place. | ClinicalTrials.gov |
| Other | Body Mass Index | From enrollment only | Body Mass Index (BMI) will be assessed to identify the moderating role of obesity on pain interference and executive function. Weight and height will be combined to report BMI in kg/m\^2). | ClinicalTrials.gov |
| Other | Physical Performance Test Battery for Sarcopenia (1 of 6) | From enrollment to the end of treatment at 8 weeks | (1) Hand Grip Strength using a JAMAR® dynamometer, adjusted to fit participants' hands as described elsewhere. A minimum of three trials with 60 seconds of rest between trials, and additional trials if the highest two values differ by more than 3 kg. Unit: Force in kilograms The investigators will diagnose sarcopenia using the European Working Group's (EWGSOP2) revised consensus definition, which involves assessing two measures and current sarcopenia reference values: (i) hand grip strength via dynamometry and (ii) gait speed. | ClinicalTrials.gov |
| Other | Physical Performance Test Battery for Sarcopenia (2 of 6) | From enrollment to the end of treatment at 8 weeks | (2) Usual Gait Speed over 4 meters to assess for gait speed. Unit: Seconds The investigators will diagnose sarcopenia using the European Working Group's (EWGSOP2) revised consensus definition, which involves assessing two measures and current sarcopenia reference values: (i) hand grip strength via dynamometry and (ii) gait speed. | ClinicalTrials.gov |
| Other | Physical Performance Test Battery for Sarcopenia (3 of 6) | From enrollment to the end of treatment at 8 weeks | (3) Six Minute Walk Test to assess for submaximal aerobic walking capacity. Unit: Meters | ClinicalTrials.gov |
| Other | Physical Performance Test Battery for Sarcopenia (4 of 6) | From enrollment to the end of treatment at 8 weeks | (4) Four-Square Step Test to assess for dynamic balance that involves stepping over objects forward, sideways, and backward. Unit: Seconds | ClinicalTrials.gov |
| Other | Physical Performance Test Battery for Sarcopenia (5 of 6) | From enrollment to the end of treatment at 8 weeks | (5) 5x Repeated Sit-to-Stand Test to assess lower extremity strength. Unit: Seconds | ClinicalTrials.gov |
| Other | Physical Performance Test Battery for Sarcopenia (6 of 6) | From enrollment to the end of treatment at 8 weeks | (6) Stair Climb Power Test to assess lower extremity power. Unit: Seconds. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 2
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Category Fluency | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)