Trial · NCT06873035
An Interventional Study of Infigratinib in Children With Hypochondroplasia
NCT06873035, Phase 2, Phase 3, Enrolling by invitation, QED Therapeutics, a BridgeBio company
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. An Interventional Study of Infigratinib in Children With Hypochondroplasia. Trials, record NCT06873035. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06873035
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- An Interventional Study of Infigratinib in Children With Hypochondroplasia
- NCT number
- NCT06873035
- Status
- Enrolling by invitation
- Phases
- Phase 2, Phase 3
- Enrollment
- 24 participants, estimated
- Lead sponsor
- QED Therapeutics, a BridgeBio company
- Conditions
- Hypochondroplasia
- Interventions
- infigratinib 0.128 mg/kg/day, infigratinib 0.25 mg/kg/day
- First posted
- 2025-03-12
- Last updated
- 2026-07-16
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change from baseline (BL) in Annualized Height Velocity (AHV; cm/year) | 26 weeks | |
| Primary | Incidence, severity, and seriousness of adverse events (AEs) that require dose reduction or discontinuation | at least 26 weeks | |
| Secondary | Change from BL in height Z-score (in relation to both HCH and average height tables) | 52 weeks | |
| Secondary | Change from BL in upper to lower body segment ratio (cm) | 52 weeks | |
| Secondary | Changes in cognitive function (as assessed by age appropriate computerized tests) | 52 weeks | |
| Secondary | Pharmacokinetic profile of infigratinib by assessment of maximum concentration (Cmax) | 52 weeks | |
| Secondary | Pharmacokinetic profile of infigratinib by assessment of time-to-maximum concentration (Tmax) | 52 weeks | |
| Secondary | Change from BL in collagen X marker (CXM) levels | 52 weeks | |
| Other | Change from BL in comorbidities associated with HCH | 52 weeks | |
| Other | Change from BL in Health-related Quality of Life (HRQoL) (as assessed by Pediatric Quality of Life Inventory [PedsQL tool]) | 52 weeks |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06873035
GET https://conductscience.org/api/trials/v1/NCT06873035/registered