Trial · NCT06899477
Pre-Operative Treatment in REseCTable COlon CanceR
NCT06899477, Phase 3, Not yet recruiting, Dominik Paul Modest
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Pre-Operative Treatment in REseCTable COlon CanceR. Trials, record NCT06899477. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06899477
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Pre-Operative Treatment in REseCTable COlon CanceR
- NCT number
- NCT06899477
- Status
- Not yet recruiting
- Phases
- Phase 3
- Enrollment
- 714 participants, estimated
- Lead sponsor
- Dominik Paul Modest
- Conditions
- Colo-rectal Cancer, Colon Cancer, Colon Carcinoma
- Interventions
- mFOLFOXIRI, mFOLFOX-6, CAPOX
- First posted
- 2025-03-28
- Last updated
- 2025-03-28
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Disease-free survival (DFS) | LPI + 36 months (96 months total) | Disease-free survival (DFS) - defined as no surgery, no resection, incomplete resection, disease recurrence (new metastases or local relapse) and death from any cause from the time of randomization. In case of no surgery ,no resection, or incomplete resection (defined as R2 resection = macroscopic tumor rest), the timepoint of the respective event will be set to two weeks after randomization to avoid time-bias in favor of the experimental/neoadjuvant therapy arm. |
| Secondary | Overall survival (OS) | LPI + 60 months (120 months total) | time from randomization to the date of death of any cause |
| Secondary | Tumor regression grades (TRS) | LPI + 60 months (120 months total) | according to Dworak's score |
| Secondary | (Serious) Adverse Events | LPI + 60 months (120 months total) | Type, incidence, severity, and causal relationship to active chemotherapy of non-serious adverse events and serious adverse events (severity evaluated according to CTCAE version 5.0), rate of surgery complication scores (Clavien Dindo) |
| Secondary | Quality of life (QoL) | LPI + 60 months (120 months total) | assessed with the QoL questionnaire EQ-5D-5L |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 41857556 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06899477
GET https://conductscience.org/api/trials/v1/NCT06899477/registered