Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes
NCT06906276, Recruiting, Karolinska Institutet
Trial 9
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes | ClinicalTrials.gov |
| NCT number | NCT06906276 | ClinicalTrials.gov |
| Status | Recruiting | ClinicalTrials.gov |
| Enrollment | 30 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Karolinska Institutet | ClinicalTrials.gov |
| Conditions | Gait Disorders, Neurologic, Atypical Parkinson Disease, fNIRS, Aging | ClinicalTrials.gov |
| Interventions | Assessment of brain activity with fNIRS and behavioural assessments (motor, motor-cognitive and cognitive) during three complex walking conditions. | ClinicalTrials.gov |
| First posted | 2025-04-02 | ClinicalTrials.gov |
| Last updated | 2026-10-22 | ClinicalTrials.gov |
Registered outcomes 17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Functional near infrared spectrometry (fNIRS) | Baseline | The measurement of changes in concentration of HbO and HHb in the prefrontal cortex will be assessed using a NIRSPORT 2 (NIRx Medizintechnik, Berlin, Germany) device. | ClinicalTrials.gov |
| Primary | Gait performance during all conditions | Baseline | Gait variables such as stride time and/or velocity will be analyzed with the APDM mobility system. | ClinicalTrials.gov |
| Primary | Dual-task performance-reaction time | Baseline | Cognitive performance of the dual task will be assessed as errors in the response to the Auditory Stroop task. | ClinicalTrials.gov |
| Secondary | Resting-state functional near infrared spectrometry (rsfNIRS) | Baseline | The measurement of changes in concentration of HbO and HHb in the whole cortex will be assessed using a NIRSPORT 2 (NIRx Medizintechnik, Berlin, Germany) device during 2x 10min of rest, while seated in a comfortable chair. | ClinicalTrials.gov |
| Secondary | Cognitive function- composite score | Baseline | The cognitive test battery comprised the following tests: The Color-Word Interference Test (CWIT), Verbal Fluency, Trail Making Test (TMT), Ray Auditory Verbal Learning Test (RAVLT), and Symbol Digit Modalities Test (SDMT). Cognitive function will be assessed as a composite measure of these tests together. | ClinicalTrials.gov |
| Secondary | Cognitive function - verbal fluency | Baseline | Verbal function, initiation \& task-set switching with the Verbal Fluency test from D-KEFS (Delis-Kaplan Executive Function System). | ClinicalTrials.gov |
| Secondary | Cognitive function - Attention and psychomotor processing speed | Baseline | Attention and psychomotor processing speed will be assessed with the Trail Making Test (TMT) from D-KEFS (Delis-Kaplan Executive Function System). | ClinicalTrials.gov |
| Secondary | Cognitive function - Episodic memory | Baseline | Episodic memory will be assessed with the Ray Auditory Verbal Learning Test (RAVLT). | ClinicalTrials.gov |
| Secondary | Cognitive function - Inhibition & task-set switching | Baseline | Inhibition \& task-set switching with the Color-Word Interference Test (CWIT) from D-KEFS (Delis-Kaplan Executive Function System) | ClinicalTrials.gov |
| Secondary | Self-reported level of physical activity | Baseline | Assessed with the Frändin-Grimby Scale (score 1-6, higher score=better) | ClinicalTrials.gov |
| Secondary | Physical activity | Baseline | Assessed with accelerometers (Actigraph GT3X+) for seven consecutive days after the clinical visit | ClinicalTrials.gov |
| Secondary | Motor function/disease severity | Baseline | Assessed with the movement Disorders Society- Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Higher scores = worse/more symptoms | ClinicalTrials.gov |
| Secondary | Balance performance | Baseline | Assessed with the Mini-BESTest (Balance Evaluation Systems test), 0-28p, | ClinicalTrials.gov |
| Secondary | Anxiety and depression | Baseline | Assessed with Hospital Anxiety and Depression Scale (HADS), 0-24 on the depression and anxiety part respectively. Lower score=better | ClinicalTrials.gov |
| Secondary | Walking ability | Baseline | Self-assessed walking ability with the WALK-12G. | ClinicalTrials.gov |
| Secondary | Dual-task performance -errors | Baseline | Cognitive performance of the dual task will be assessed as the reaction time to respond during the Auditory Stroop | ClinicalTrials.gov |
| Secondary | Disability | Baseline | WHO Disability Assessment Schedule (WHODAS) version 2.0, 12 self-assessed questions (12 to 60) more points=worse | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 6
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)