Trial · NCT06923540
Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption
NCT06923540, Phase 4, Not yet recruiting, Centre hospitalier de l'Université de Montréal (CHUM)
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption. Trials, record NCT06923540. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06923540
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption
- NCT number
- NCT06923540
- Status
- Not yet recruiting
- Phases
- Phase 4
- Enrollment
- 140 participants, estimated
- Lead sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
- Conditions
Post Operative Analgesia, Opioid Consumption, Postoperative, Acetaminophen, Abdominal Surgeries, Post Operative Bowel Dysfunction, Post Operative Nausea and Vomiting, Post Operative Pain Control, Mobility, Epidural Analgesia, Length of Stay, Pain Management
- Interventions
- IV Acetaminophen
- First posted
- 2025-04-11
- Last updated
- 2025-04-11
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Opioid consumption in oral morphine milligram equivalents (MME) | 72 hours | To determine whether the systematic use of IV acetaminophen in adult NPO patients in the postoperative context of abdominal surgery (post-intervention) reduces the average opioid consumption in oral morphine milligram equivalents (MME) over 72 hours compared to the standard protocol, which includes PO or IR acetaminophen (pre-intervention). |
| Secondary | Opioid consumption (converted to MME) at 24 and 48 hours postoperatively | 48 hours | To determine whether the systematic use of IV acetaminophen reduces the average opioid consumption in MME over the first 24 and 48 postoperative hours in the post-intervention period compared to the pre-intervention period. |
| Other | Pain level at rest (on a scale from 0 to 10) during the first 72 hours. | 72 hours | Compare the variation in resting pain levels during the periods of 0 to 24 hours, 24 to 48 hours, 0 to 48 hours, 48 to 72 hours, and 0 to 72 hours between the pre-intervention and post-intervention periods. This simple scale asks patients to rate their pain on a scale from zero (no pain) to ten (maximum pain). |
| Other | Pain level during mobilization (on a scale from 0 to 10) during the first 72 hours | 72 hours | Compare the average pain level during mobilization (upon standing) on postoperative days 0, 1, and 2 between the pre-intervention and post-intervention periods. This simple scale asks patients to rate their pain on a scale from zero (no pain) to ten (maximum pain) |
| Other | Length of hospital stay | From date of the abdominal surgery until the date of hospital discharge, assessed up to 6 months | Compare the length of hospital stay in days from the end of surgery until hospital discharge between the pre-intervention and post-intervention periods. |
| Other | Nausea and constipation (antiemetic doses, laxative use) | 72 hours | Compare the frequency of nausea and constipation between the pre-intervention and post-intervention periods |
| Other | Functionality: time to first mobilization, mean chair time on postoperative days 1 and 2, time to return of oral intake, time to epidural discontinuation. | 72 hours | Compare the average time (in days) before the return of an uncompromised enteral route, complete epidural weaning, and first mobilization (first time standing up) between the pre-intervention and post-intervention periods. Compare the average time spent seated in a chair on postoperative days 1 and 2 between the pre-intervention and post-intervention periods. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06923540
GET https://conductscience.org/api/trials/v1/NCT06923540/registered