Trial · NCT06937229
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
NCT06937229, Phase 3, Recruiting, Bristol-Myers Squibb
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3). Trials, record NCT06937229. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06937229
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
- NCT number
- NCT06937229
- Status
- Recruiting
- Phases
- Phase 3
- Enrollment
- 650 participants, estimated
- Lead sponsor
- Bristol-Myers Squibb
- Conditions
- Alzheimer Disease, Agitation
- Interventions
- KarXT, KarX-EC
- First posted
- 2025-04-22
- Last updated
- 2026-11-12
Source ClinicalTrials.gov
Registered outcomes18
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of Participants With Treatment Emergent Adverse Events (TEAEs) | Up to approximately Week 30 | |
| Secondary | Number of Participants With Adverse Events (AEs) | Up to approximately Week 30 | |
| Secondary | Number of Participants With Serious AEs (SAEs) | Up to approximately Week 30 | |
| Secondary | Number of Participants With TEAEs Leading to Study Withdrawal | Up to approximately Week 30 | |
| Secondary | Number of Participants With TEAEs Leading to Death | Up to approximately Week 30 | |
| Secondary | Number of Participants with Adverse Events of Special Interest (AESI) | Up to approximately Week 30 | |
| Secondary | Change From Baseline in Barnes Akathisia Rating Scale (BARS) | Up to approximately Week 26 | |
| Secondary | Change From Baseline in Abnormal Involuntary Movement Scale (AIMS) | Up to approximately Week 26 | |
| Secondary | Change From Baseline in Body Weight | Up to approximately Week 26 | |
| Secondary | Change From Baseline in Body Mass Index (BMI) | Up to approximately Week 26 |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06937229
GET https://conductscience.org/api/trials/v1/NCT06937229/registered