AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions
NCT06950060, Not applicable, Active not recruiting, University of Alabama at Birmingham
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions | ClinicalTrials.gov |
| NCT number | NCT06950060 | ClinicalTrials.gov |
| Status | Active not recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 48 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | University of Alabama at Birmingham | ClinicalTrials.gov |
| Conditions | Stroke, Chronic, Aging, Cognitive Decline, Motor Dysfunction, Neuroplasticity | ClinicalTrials.gov |
| Interventions | High intensity cycling, Low-intensity cycling, Health education session, Moderate Intensity Aerobic Exercise | ClinicalTrials.gov |
| First posted | 2025-04-29 | ClinicalTrials.gov |
| Last updated | 2026-07-17 | ClinicalTrials.gov |
Registered outcomes 5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Motor Learning Performance (12-Digit Serial Reaction Time Task) | Baseline, Day 2, Day 3, Day 4, and Day 5 | Motor learning is assessed using the 12-digit Serial Reaction Time Task (SRTT), a computer-based measure of implicit motor sequence learning. Participants respond to visual cues by pressing buttons in a fixed or random sequence. Learning is quantified by changes in reaction time and accuracy across structured and unstructured trials. A learning index is derived by comparing performance between patterned (learning) and random sequences. | ClinicalTrials.gov |
| Secondary | Change in Long-Interval Intracortical Inhibition (LICI) | Baseline, Day 5 | LICI is measured using a 100 ms interstimulus interval to assess GABA\<sub\>B\</sub\>-mediated inhibition. Recorded before and after each intervention session. | ClinicalTrials.gov |
| Secondary | Change in Intracortical Facilitation (ICF) | Baseline, Day 5 | ICF is assessed using paired-pulse TMS with a 10-15 ms interstimulus interval to evaluate cortical excitability. | ClinicalTrials.gov |
| Secondary | Change in Blood Lactate Concentration | Day 2, Day 3, Day 4 | Measured via fingerstick blood samples pre-, mid-, and post-exercise. | ClinicalTrials.gov |
| Secondary | Change in Executive Function (D-KEFS Verbal Fluency and Stroop Tests) | Day 1 and Day 5 | Executive function neuropsychological tests. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 4
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Motor Sequence Task | Primary outcome | ConductCognition |
| Serial Reaction Time | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)