Trial · NCT06950294
iNO300 Therapy in Critically Ill Patients With Pneumonia
NCT06950294, Early phase 1, Recruiting, Massachusetts General Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. iNO300 Therapy in Critically Ill Patients With Pneumonia. Trials, record NCT06950294. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06950294
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- iNO300 Therapy in Critically Ill Patients With Pneumonia
- NCT number
- NCT06950294
- Status
- Recruiting
- Phases
- Early phase 1
- Enrollment
- 34 participants, estimated
- Lead sponsor
- Massachusetts General Hospital
- Conditions
- Critical Illness, Pneumonia
- Interventions
- High dose inhaled nitric oxide, Sham treatment, standard therapy
- First posted
- 2025-04-30
- Last updated
- 2026-05-22
Source ClinicalTrials.gov
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Peaks of methomoglobin | From Day 1 to Day 5 | Continuous recording of MetHb and peaks of MetHb will be determined. |
| Secondary | Nitrogen dioxide level | From Day 1 to Day 5 | Continuous measurement of nitrogen dioxide concentration in the inspiratory limb of breathing circuit |
| Secondary | Feasibility | From enrollment to Day 60 | Referral, recruitment, retention, compliance and follow-up completion rates of the study |
| Secondary | Clinical cure rate of pneumonia | From enrollment to test of cure day (4 -11 days post end of treatment) | Clinical cure is assessed at test of cure (4 -11 days post end of treatment) and defined as resolution of clinical signs and symptoms of pneumonia compared with baseline, including a reduction in SOFA and CPIS scores, improvement or lack of progression in chest imaging, and no requirement for additional antibacterial treatment. |
| Secondary | Clinical improvement rate of pneumonia | Day 5 | Clinical improvement is assessed at end of treatment and defined as improvement in 2 or more clinical signs and symptoms of pneumonia compared with baseline, improvement or lack of progression of chest x-ray abnormalities, and no requirement for additional antibacterial treatment. Clinical signs and symptoms of pneumonia include new onset or worsening cough, purulent sputum or increased suction requirements, auscultation findings of pneumonia, dyspnea, tachypnea, or respiratory rate ≥ 30/min, hypoxemia, worsening gas exchange. |
| Secondary | Microbiologic eradication rate | From enrollment to test of cure day (4 -11 days post end of treatment) | Absence of the baseline pathogen from tracheal aspiration or bronchoalveolar lavage fluid will be confirmed. If it is not possible to obtain an appropriate clinical specimen for culture and the patient has a successful clinical outcome, the response was presumed to be eradication. |
| Secondary | 28-day all cause mortality | From enrollment to Day 28 | All cause mortality from enrollment to Day 28 |
| Secondary | 60-day all cause mortality | From enrollment to Day 60 | All cause mortality from enrollment to Day 60 |
| Secondary | 28-day ventilator free days | From enrollment to Day 28 | Successful liberation from mechanical ventilation should last more than 48 h without re-intubation in patients who have survived 28 days after randomization (extubation was counted from the last successful attempt in patients who have survived 28 days since randomization) and for patients ventilated for 28 days or more or who died before 28 days (irrespective of intubation status), the number of ventilator-free days was recorded at zero. |
| Secondary | Days free from organ support in 28 days | From enrollment to Day 28 | Organ support includes mechanical ventilation, vasopressors and renal replacement therapy. |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers10
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06950294
GET https://conductscience.org/api/trials/v1/NCT06950294/registered