Resilience Among Individuals With Opioid Use Disorder
NCT06954402, Not applicable, Recruiting, Johns Hopkins University
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Resilience Among Individuals With Opioid Use Disorder | ClinicalTrials.gov |
| NCT number | NCT06954402 | ClinicalTrials.gov |
| Status | Recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 125 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Johns Hopkins University | ClinicalTrials.gov |
| Conditions | Opioid Use Disorder | ClinicalTrials.gov |
| Interventions | Acute Stress Intervention (MAST-based), Non-Stress Intervention (NST-based) | ClinicalTrials.gov |
| First posted | 2025-05-01 | ClinicalTrials.gov |
| Last updated | 2026-06-23 | ClinicalTrials.gov |
Registered outcomes 13
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Self-Reported Trait Resilience as assessed by Connor-Davidson Resilience Scale 25 (CD-RISC-25) | Immediately after completing the task | Instrument: Connor-Davidson Resilience Scale 25 Score Range: 0-100 Interpretation: Higher scores indicate greater resilience. | ClinicalTrials.gov |
| Primary | Cognitive Flexibility: Stroop Color-Word Test reaction time | Immediately after completing the task | Instrument: Stroop Color-Word Test Unit: Milliseconds (ms) Interpretation: Higher values = slower performance (worse) | ClinicalTrials.gov |
| Primary | Emotional Flexibility: Emotional Stroop Task reaction time | Immediately after completing the task | Instrument: Emotional Stroop Task Unit: Milliseconds (ms) Interpretation: Higher values = slower performance (worse). | ClinicalTrials.gov |
| Primary | Perceived Controllability (Controllable) assessed by Social Controllability Task (SCT) | Immediately after completing the task | Instrument: Social Controllability Task Description: Participants ratings on a 0-100% sliding scale. Interpretation: Higher scores indicate greater perceived control. | ClinicalTrials.gov |
| Secondary | Subjective Effects of Stress as assessed by the Subjective Effects Visual Analog Scale (VAS) Battery | Immediately after completing the task | Instrument: Subjective Effects Visual Analog Scale (VAS) Battery Instrument: VAS (0-100 mm) Interpretation: Higher scores indicate greater intensity of each subjective state. | ClinicalTrials.gov |
| Secondary | Heart Rate | Immediately after completing the task | Unit: Beats per minute (bpm) Interpretation: Higher = increased arousal | ClinicalTrials.gov |
| Secondary | Systolic Blood Pressure | Immediately after completing the task | Unit: mmHg Interpretation: Higher = greater pressure. | ClinicalTrials.gov |
| Secondary | Diastolic Blood Pressure | Immediately after completing the task | Unit: mmHg Interpretation: Higher = greater pressure. | ClinicalTrials.gov |
| Secondary | Opioid Demand Breakpoint as assessed by the Hypothetical Purchase Task | Immediately after completing the task | Instrument: Hypothetical Purchase Task Range: $0-$500 Interpretation: Higher = greater demand. | ClinicalTrials.gov |
| Secondary | Percentage of Resilience-themed Interview Content | Up to 1 year | This outcome is defined as the average percentage of narrative content within semi-structured qualitative interviews classified as "resilience-themed" using Latent Dirichlet Allocation (LDA). This measure quantifies the relative focus a participant places on adaptive coping and recovery narratives | ClinicalTrials.gov |
| Secondary | Percentage of Spirituality-themed Interview Content | Up to 1 year | This outcome is defined as the average percentage of narrative content within semi-structured qualitative interviews classified as "spirituality-themed" using Latent Dirichlet Allocation (LDA). This measure quantifies the relative focus a participant places on spiritual or existential frameworks as a component of their recovery. | ClinicalTrials.gov |
| Secondary | Mean Narrative Sentiment Valence Score | Up to 1 year | A quantitative emotional-tone score calculated from participant interview transcripts using a standardized sentiment analysis algorithm. The score range is -1 to +1. A score of -1 represents a highly negative emotional valence, while a score of +1 represents a highly positive emotional valence. Higher scores indicate a more positive emotional narrative. | ClinicalTrials.gov |
| Secondary | Incremental Variance (∆R2) in Stress-Induced Opioid Demand Predicted by NLP Indices | From baseline up to 1 year | This outcome measures the change in R-squared (∆R2) when NLP-derived indices (topic proportions and sentiment) are added to a sequential regression model that already includes self-report and behavioral task scores. This measurement will be performed only on the subset of 45 participants who complete the qualitative interview sub-study. The outcome being predicted is the difference in opioid purchase breakpoints between the stress (MAST) and no-stress conditions. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|---|---|---|---|---|---|
| K08DA058057 | A Novel Human Laboratory Model of Resilience Among Individuals with Opioid Use Disorder | MARTINEZ, SUKY | JOHNS HOPKINS UNIVERSITY | NATIONAL INSTITUTE ON DRUG ABUSE | 2024 to 2025 | NIH RePORTER |
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 3
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Emotional Stroop Task | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Purchase Task | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)