Trial · NCT06987097
Ambrisentan for Early Low-Risk Pulmonary Arterial Hypertension
NCT06987097, Not applicable, Not yet recruiting, Nanjing First Hospital, Nanjing Medical University
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Ambrisentan for Early Low-Risk Pulmonary Arterial Hypertension. Trials, record NCT06987097. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06987097
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Ambrisentan for Early Low-Risk Pulmonary Arterial Hypertension
- NCT number
- NCT06987097
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 410 participants, estimated
- Lead sponsor
- Nanjing First Hospital, Nanjing Medical University
- Conditions
- Pulmonary Arterial Hypertension (PAH)
- Interventions
- Ambrisentan, Placebo
- First posted
- 2025-05-23
- Last updated
- 2025-05-23
Source ClinicalTrials.gov
Registered outcomes23
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | The primary efficacy endpoint is the composite of pulmonary hypertension progression at 12 months | baseline,12 months | defined as meeting any of the following criteria within 12 months: 1. mPAP ≥ 25 mmHg OR PVR \> 3 WUs as measured by RHC OR 2. worsening of risk stratification compared to baseline, defining as at least one class progression based on the simplified four-tier model of the 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension |
| Secondary | systolic PAP (sPAP) by Hemodynamic measurements | baseline,12 months | |
| Secondary | mPAP by Hemodynamic measurements | baseline,12 months | |
| Secondary | cardiac output (CO) by Hemodynamic measurements | baseline,12 months | |
| Secondary | cardiac index (CI) by Hemodynamic measurements | baseline,12 months | |
| Secondary | PVR by Hemodynamic measurements | baseline,12 months | |
| Secondary | PVRi by Hemodynamic measurements | baseline,12 months | |
| Secondary | PAWP by Hemodynamic measurements | baseline,12 months | |
| Secondary | right atrial pressure by Hemodynamic measurements | baseline,12 months | |
| Secondary | pulmonary arterial compliance by Hemodynamic measurements | baseline,12 months |
1 to 10 of 23Source ClinicalTrials.gov
See all 23 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 41653169 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06987097
GET https://conductscience.org/api/trials/v1/NCT06987097/registered?page=2