Trial · NCT06994442
Optimizing Pain Treatment in Children On Mechanical Ventilation
NCT06994442, Phase 3, Recruiting, Weill Medical College of Cornell University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Optimizing Pain Treatment in Children On Mechanical Ventilation. Trials, record NCT06994442. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06994442
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Optimizing Pain Treatment in Children On Mechanical Ventilation
- NCT number
- NCT06994442
- Status
- Recruiting
- Phases
- Phase 3
- Enrollment
- 644 participants, estimated
- Lead sponsor
- Weill Medical College of Cornell University
- Conditions
- Mechanical Ventilation, Pediatric Acute Respiratory Failure, Analgesics, Opioid, Sedation and Analgesia
- Interventions
- Acetaminophen, Ketorolac, Placebo
- First posted
- 2025-05-29
- Last updated
- 2026-10-29
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Acute Pain Episodes | First 5 days of mechanical ventilation or until extubation, whichever comes first | Pain will be assessed using the Face, Legs, Activity, Cry, Consolability (FLACC) score. Coma will be defined using standardized sedation scales. The number of time periods where the participant is both pain-free (FLACC \<4) and coma-free will be recorded. |
| Secondary | Opioid Exposure | First 5 days of mechanical ventilation or until extubation, whichever comes first | Opioid exposure will be quantified in morphine milligram equivalents per kilogram during the first 5 days of mechanical ventilation. |
| Secondary | Benzodiazepine Exposure | First 5 days of mechanical ventilation or until extubation, whichever comes first | Total benzodiazepine exposure (in midazolam milligram equivalents per kilogram) during the first 5 days of mechanical ventilation. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| U01HD116260 | Optimizing Pain Treatment In Children On Mechanical ventilation (OPTICOM) | TRAUBE, CHANI; BELL, MICHAEL JAMES; HOLUBKOV, RICHARD | WEILL MEDICAL COLL OF CORNELL UNIV | EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT | 2024 to 2025 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06994442
GET https://conductscience.org/api/trials/v1/NCT06994442/registered