Trial · NCT07037758
A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)
NCT07037758, Phase 1, Recruiting, Amgen
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311). Trials, record NCT07037758. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07037758
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)
- NCT number
- NCT07037758
- Status
- Recruiting
- Phases
- Phase 1
- Enrollment
- 380 participants, estimated
- Lead sponsor
- Amgen
- Conditions
- Extensive Stage Small Cell Lung Cancer
- Interventions
- Tarlatamab, AB248
- First posted
- 2025-06-25
- Last updated
- 2026-09-25
Source ClinicalTrials.gov
Registered outcomes15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of Participants with Treatment-emergent Adverse Events (TEAEs) | Up to 2.5 years | Clinically significant changes in vital signs and clinical laboratory tests will be reported as adverse events. |
| Primary | Dose Exploration: Number of Participants with Dose-limiting Toxicities (DLTs) | Up to 35 days | |
| Secondary | Maximum Serum Concentration (Cmax) of Tarlatamab | Up to approximately 21 weeks | |
| Secondary | Minimum Serum Concentration (Cmin) of Tarlatamab | Up to approximately 21 weeks | |
| Secondary | Area Under the Concentration-time Curve (AUC) of Tarlatamab | Up to approximately 21 weeks | |
| Secondary | Half-life (t1/2) of Tarlatamab | Up to approximately 21 weeks | |
| Secondary | Objective Response (OR) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 | Up to 2.5 years | |
| Secondary | Duration of Response (DOR) per RECIST 1.1 | Up to 2.5 years | |
| Secondary | Time to Response (TTR) per RECIST 1.1 | Up to 2.5 years | |
| Secondary | Disease Control (DC) per RECIST 1.1 | Up to 2.5 years |
1 to 10 of 15Source ClinicalTrials.gov
See all 15 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07037758
GET https://conductscience.org/api/trials/v1/NCT07037758/registered