Investigation of the Acute Effects of Nepalese Pepper Extract (Zanthoxylum Armatum DC) on Cognitive Function, Mood and Gaming Performance in Young, Healthy, Competitive Gamers
NCT07047105, Not applicable, Completed, Northumbria University
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Investigation of the Acute Effects of Nepalese Pepper Extract (Zanthoxylum Armatum DC) on Cognitive Function, Mood and Gaming Performance in Young, Healthy, Competitive Gamers | ClinicalTrials.gov |
| NCT number | NCT07047105 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 57 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Northumbria University | ClinicalTrials.gov |
| Conditions | Cognition, Mood, Gaming Performance, Fatigue | ClinicalTrials.gov |
| Interventions | Nepalese Pepper (Zanthoxylum Armatum) extract 150mg, Nepalese Pepper (Zanthoxylum Armatum) extract 300mg, Placebo, Caffeine 75mg | ClinicalTrials.gov |
| First posted | 2025-07-02 | ClinicalTrials.gov |
| Last updated | 2026-07-15 | ClinicalTrials.gov |
Registered outcomes 17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Speed of Attention | Prior to intervention on each testing visit for each arm, along with post dose 1 hour, post dose 3 hour and post dose 5 hour. | Score calculated through performance on Rapid Visual Information Processing, Simple Reaction Time and Choice Reaction Time | ClinicalTrials.gov |
| Primary | Subjective Fatigue | Prior to intervention on each testing visit for each arm, along with post dose 1 hour, post dose 3 hour and post dose 5 hour. | Following completion of Cognitive Demand Battery subjective fatigue will be assessed through self assessment of fatigue levels. | ClinicalTrials.gov |
| Secondary | Accuracy of Attention | Prior to intervention on each testing visit for each arm, along with post dose 1 hour, post dose 3 hour and post dose 5 hour. | Score calculated through combined performance on Rapid Visual Information Processing and Choice Reaction Time tasks | ClinicalTrials.gov |
| Secondary | Speed of Performance | Prior to intervention on each testing visit for each arm, along with post dose 1 hour, post dose 3 hour and post dose 5 hour. | Score calculated through combined performance on Numeric Working Memory, SRT, CRT, RVIP, Stroop, Delayed Picture Recognition, Delayed Word Recognition | ClinicalTrials.gov |
| Secondary | Accuracy of Performance | Prior to intervention on each testing visit for each arm, along with post dose 1 hour, post dose 3 hour and post dose 5 hour. | Score calculated through combined performance on Immediate Word Recall, CRT, Corsi Blocks, RVIP, Stroop, Delayed Word Recall, Delayed Picture Recognition, Delayed Word Recognition | ClinicalTrials.gov |
| Secondary | Working memory | Prior to intervention on each testing visit for each arm, along with post dose 1 hour, post dose 3 hour and post dose 5 hour. | Score calculated through combined performance on Numeric Working Memory, Corsi Blocks | ClinicalTrials.gov |
| Secondary | Speed of memory | Prior to intervention on each testing visit for each arm, along with post dose 1 hour, post dose 3 hour and post dose 5 hour. | Score calculated through combined performance on Numeric Working Memory, Delayed Picture Recognition, Delayed Word Recognition | ClinicalTrials.gov |
| Secondary | Episodic memory | Prior to intervention on each testing visit for each arm, along with post dose 1 hour, post dose 3 hour and post dose 5 hour. | Score calculated through combined performance on Immediate Word Recall, Delayed Word Recall, Delayed Picture Recognition, Delayed Word Recognition | ClinicalTrials.gov |
| Secondary | Executive Function | Prior to intervention on each testing visit for each arm, along with post dose 1 hour, post dose 3 hour and post dose 5 hour. | Score calculated through score on Peg and Ball and Stroop interference | ClinicalTrials.gov |
| Secondary | Mood | Prior to intervention on each testing visit for each arm, along with post dose 1 hour, post dose 3 hour and post dose 5 hour. | Mood rating calculated through answers to Visual Analogue Mood Scales and Positive and Negative Affect Schedule | ClinicalTrials.gov |
| Secondary | Heart Rate Variability (HRV) | Prior to intervention on each testing visit for each arm, along with post dose 40 minutes, post dose 160 minutes and post dose 220 minutes. | HRV | ClinicalTrials.gov |
| Secondary | Multi Tasking Ability | Prior to intervention on each testing visit for each arm, along with post dose 40 minutes, post dose 160 minutes and post dose 220 minutes. | Multi Tasking Ability measured through Multi Tasking Framework score | ClinicalTrials.gov |
| Secondary | First Person Shooter Aiming Ability | Prior to intervention on each testing visit for each arm, along with post dose 40 minutes, post dose 160 minutes and post dose 220 minutes. | First Person Shooter Aiming Ability with a mouse measured through performance on an aim trainer (Aim Labs) | ClinicalTrials.gov |
| Secondary | Finger Tapping Task | Prior to intervention on each testing visit for each arm, along with post dose 40 minutes, post dose 160 minutes and post dose 220 minutes. | Number of finger taps in 10 seconds | ClinicalTrials.gov |
| Secondary | MOBA Control Ability | Prior to intervention on each testing visit for each arm, along with post dose 40 minutes, post dose 160 minutes and post dose 220 minutes. | Measure of character control ability using a custom MOBA style game to test movement and input ability. | ClinicalTrials.gov |
| Secondary | Subjective Gameplay Performance | At home on the evening at least 6 hours post dose, on each testing visit following gameplay. | Subjective Performance Gameplay Scale self report by participants | ClinicalTrials.gov |
| Secondary | Tracked Game Performance | At home on the evening at least 6 hours post dose, on each testing visit following gameplay. | Online tracking of game performance using participant game profile information to assess performance through various in game metrics. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 7
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Choice Reaction Time | Primary outcome | ConductCognition |
| Rapid Visual Information Processing | Primary outcome | ConductCognition |
| Simple Reaction Time | Primary outcome | ConductCognition |
| Corsi Block-Tapping Test | Secondary outcome | ConductCognition |
| Delayed Recall Module | Secondary outcome | ConductCognition |
| Finger Tapping Task | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)