Trial · NCT07054645
Elderberry Functional Gum and Cognitive & Oral Health in Older Adults
NCT07054645, Not applicable, Not yet recruiting, Burdur Mehmet Akif Ersoy University
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Elderberry Functional Gum and Cognitive & Oral Health in Older Adults. Trials, record NCT07054645. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07054645
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Elderberry Functional Gum and Cognitive & Oral Health in Older Adults
- NCT number
- NCT07054645
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 34 participants, estimated
- Lead sponsor
- Burdur Mehmet Akif Ersoy University
- Conditions
- Mild Cognitive Impairment (MCI), Aging, Oral Microbiome
- Interventions
- Elderberry Anthocyanin Chewing Gum, Placebo Chewing Gum
- First posted
- 2025-07-08
- Last updated
- 2025-07-08
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Cognitive Function Assessed by MoCA (Montreal Cognitive Assessment) Score | Baseline and Week 6 | The MoCA score (0-30) will be used to assess global cognitive function. A higher score indicates better cognitive performance. Measurements will be taken at baseline and at 6 weeks. |
| Secondary | Change in Executive Function Assessed by Stroop Test | Baseline and Week 6 | Cognitive flexibility and executive control will be assessed using the Stroop Color-Word Test (TBAG form). The interference score (difference in reaction time between incongruent and color conditions) will be used as the main outcome. Unit of Measure: milliseconds (ms) |
| Secondary | Change in Alpha Diversity Assessed by Shannon Index | Baseline and Week 6 | lpha diversity of oral microbiota will be assessed using the Shannon Index, based on 16S rRNA gene sequencing. Unit of Measure: Shannon diversity index (unitless) |
| Secondary | Change in Beta Diversity Assessed by UniFrac and Bray-Curtis Distances | Baseline and Week 6 | Beta diversity of oral microbiota will be assessed using UniFrac and Bray-Curtis distances, based on 16S rRNA gene sequencing. Unit of Measure: Distance metric (unitless) |
| Secondary | Change in Salivary Flow Rate | Baseline and Week 6 | Unstimulated whole saliva will be collected for 5 minutes. Flow rate will be calculated and expressed in mL/min. Differences from baseline to week 6 will be analyzed. |
| Secondary | Change in Salivary pH | Baseline and Week 6 | Salivary pH will be measured from unstimulated whole saliva samples collected over 5 minutes. Differences from baseline to week 6 will be analyzed.Unit of Measure: pH value (unitless) |
| Secondary | Change in Salivary Total Antioxidant Capacity (FRAP Method) | Baseline and Week 6 | The Ferric Reducing Antioxidant Power (FRAP) assay will be used to evaluate the total antioxidant capacity of unstimulated saliva samples. Results will be expressed as micromoles of Fe²⁺ equivalents per milliliter (µmol Fe²⁺/mL). |
| Secondary | Change in Salivary Total Phenolic Content (Folin-Ciocalteu Method) | Baseline and Week 6 | The Folin-Ciocalteu colorimetric method will be used to quantify the total phenolic content in unstimulated saliva. Results will be reported as milligrams of gallic acid equivalents per milliliter (mg GAE/mL). |
| Secondary | Change in Salivary Streptococcus mutans Count | Baseline and Week 6 | Salivary concentration of Streptococcus mutans will be assessed using microbiological culturing on selective agar. Results will be reported as colony-forming units per milliliter (CFU/mL). |
| Secondary | Change in Salivary Lactobacillus spp. Count | Baseline and Week 6 | Salivary concentration of Lactobacillus spp. will be assessed using microbiological culturing on selective agar. Results will be reported as colony-forming units per milliliter (CFU/mL). |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests1
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as |
|---|---|
| Stroop Color-Word Test | Secondary outcome |
Source ConductCognition
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07054645
GET https://conductscience.org/api/trials/v1/NCT07054645/registered