Trial · NCT07100782
Estradiol-mediated Inflammation and Central Sensitization in the Pathophysiology of Endometriosis-associated Pelvic Pain
NCT07100782, Phase 3, Recruiting, University of Michigan
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Estradiol-mediated Inflammation and Central Sensitization in the Pathophysiology of Endometriosis-associated Pelvic Pain. Trials, record NCT07100782. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07100782
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Estradiol-mediated Inflammation and Central Sensitization in the Pathophysiology of Endometriosis-associated Pelvic Pain
- NCT number
- NCT07100782
- Status
- Recruiting
- Phases
- Phase 3
- Enrollment
- 130 participants, estimated
- Lead sponsor
- University of Michigan
- Conditions
- Endometriosis, Pelvic Pain
- Interventions
- Relugolix CT
- First posted
- 2025-08-03
- Last updated
- 2026-02-18
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change score in lipopolysaccharide (LPS)-stimulated Macrophage inflammatory protein-1 alpha (MIP1-α) levels | baseline and week 12 visit | LPS-stimulated MIP1-α levels measured from whole blood |
| Primary | Change score for functional magnetic resonance imaging (fMRI) connectivity of the somatosensory cortices to the default-mode network | baseline and week 12 visit | Assessed using a functional connectivity MRI (fcMRI) at rest and applied pain |
| Secondary | Change scores for pelvic pain interference | baseline and week 12 visit | Pain interference assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS) 29+2 Profile v2.1 pain interference domain. Each domain ranges in score from 4-20 and the higher the score indicates greater pain interference in the past 7 days. |
| Secondary | Change score for temporal summation at the forearm | baseline and week 12 visit | Temporal summation is calculated as the mean difference in pain ratings evoked by the single stimuli and the trains of stimuli using a 0-100 NRS. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R01HD108253 | The impact of hormonal modulation on systemic inflammation and central sensitization | AS-SANIE, SAWSAN; SCHREPF, ANDREW | UNIVERSITY OF MICHIGAN AT ANN ARBOR | EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT | 2023 to 2025 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07100782
GET https://conductscience.org/api/trials/v1/NCT07100782/registered