Trial · NCT07109609
Topical Menthol For Tear Secretion
NCT07109609, Phase 2, Enrolling by invitation, Reinhold Vieth
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Topical Menthol For Tear Secretion. Trials, record NCT07109609. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07109609
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Topical Menthol For Tear Secretion
- NCT number
- NCT07109609
- Status
- Enrolling by invitation
- Phases
- Phase 2
- Enrollment
- 30 participants, estimated
- Lead sponsor
- Reinhold Vieth
- Conditions
- Healthy, Dry Eyes
- Interventions
- Topical application of 20% menthol solution in MCT oil., Topical Placebo Oil rolled onto the cheek.
- First posted
- 2025-08-07
- Last updated
- 2025-09-16
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Objective measure of tear stimulation Yes or No | Participant is observed for 5 minutes after application, to record tear-weight data, and the related questions that are asked are completed within 10 minutes after applicaiton. | The outcome is the binary yes/no observation of active tear secretion that overflows to the skin below the bottom eyelashes. Subject sits in still air while wearing glasses to ensure correct positioning of the topical application. The solution of menthol or placebo is dispensed from a roller-ball bottle to the right eye only, onto an area about 2cm x 2 cm just below the bottom rim of the glasses; that is, inferior to the pupil, and in line with the bottom of the nose. Within 5 minutes of sitting in still air, If moisture is evident below the bottom eyelashes, glasses are removed and tissue is dabbed, or wiped under bottom eyelash to take up the tear. If that wipe increases the weight of the tissue by at least 6 milligrams, then a "Yes" response is recorded. If after 5 minutes a wipe of tissue across the bottom eyelashes of the right eye does not increase the weight of tissue by at least 6 milligrams, a "No" is recorded to indicate that there was no increase in tear secretion. |
| Primary | Weight of tear | Measured at 5 minutes after dose application. | The actual measured weight of the tear(s) collected onto the tissue, from below the right eye. |
| Primary | Was there a subjective difference between left and right eyes in terms of sense if moisture | 5 to 10 minutes after application | Response to the question: " Which eye feels more moist? Left eye more moist or No difference (both same) or ….Right eye more moist" |
| Primary | Weight of nasal secretion blown into tissue. | Within 10 minutes of applying the dose. | The purpose is to test whether there is evidence of shared innervation of TRPM8 receptors (the menthol-responsive sensors for cold) in cornea and nasal subepithelium. The particpant holds closed the left nostril, while blowing into a tissue from the right nostril. The increase in weight of tissue is measured. |
| Secondary | Weight of nasal secretion | 5 to 10 minutes after application | Subject blows their nose into a tissue, and the increase in tissue weight is recorded. |
| Secondary | Discomfortable feeling at the treated eye. | 10 minutes | At your right eye, was there anything uncomfortable feeling? Nothing mild moderate severe (choose one) |
| Secondary | Degree of cooling or pain at the skin where the dose was applied. | 10 minutes | At the skin of the cheek, where it was rolled on, did you feel (choose one) COOLING OR NOTHING OR PAIN If cooling or pain, how strong was the feeling? (choose one) Nothing mild moderate severe |
| Secondary | Did the procedure increase sense of runny nose? | 10 minutes | Did you feel a runny nose, or nasal secretion during the 5 minutes of waiting? No or Yes And if Yes, at which nostril? Left or Right or Both nostrils |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07109609
GET https://conductscience.org/api/trials/v1/NCT07109609/registered