Trial · NCT07136987
A Trial of 2 Disease-Modifying Drugs (Metformin and N-acetylcysteine ) to Promote TB Lung Function Recovery
NCT07136987, Phase 3, Not yet recruiting, Open Source Pharma Foundation
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Trial of 2 Disease-Modifying Drugs (Metformin and N-acetylcysteine ) to Promote TB Lung Function Recovery. Trials, record NCT07136987. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07136987
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Trial of 2 Disease-Modifying Drugs (Metformin and N-acetylcysteine ) to Promote TB Lung Function Recovery
- NCT number
- NCT07136987
- Status
- Not yet recruiting
- Phases
- Phase 3
- Enrollment
- 1,104 participants, estimated
- Lead sponsor
- Open Source Pharma Foundation
- Conditions
- Tuberculosis
- Interventions
- Metformin, N-Acetylcysteine (NAC) Treatment, Standard TB treatment
- First posted
- 2025-08-22
- Last updated
- 2025-08-22
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | FEV1 | month 18 | FEV1 after adjustment for baseline covariates including FEV1, in a superiority comparison |
| Primary | Favourable treatment outcome | 18 months | Proportion of participants achieving a favourable treatment outcome (other than death, failure, recurrence, loss, default) in a non-inferiority comparison |
| Secondary | Other measures of lung function | Through month 18 | Changes in FEV1 and FVC |
| Secondary | Microbiology | Through month 6 | Clearance of MTB from sputum measured as time to stable culture conversion and as rate of change in time to detection of MTB in automated liquid cultures (MGIT TTP) |
| Secondary | Pharmacology | After 1 month of TB treatment | Plasma TB drug exposures (Cmax and AUC0-24) using population PK modeling |
| Secondary | Serious and non-serious adverse events | Through month 18 | The numbers of serious and non-serious adverse events |
| Secondary | Radiography | 18 months | Proportion of patients with persisting lung cavities on chest X ray |
| Secondary | Immunology | 2, 6, and 18 months | Blood measurements of inflammation (CRP) and immune function (IFN) |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers5
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07136987
GET https://conductscience.org/api/trials/v1/NCT07136987/registered