Registered outcomes13

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

1 to 13 of 13

List	Outcome	Time frame	Description
Primary	Alzheimers Disease Assessment Scale Cognitive section (ADAS-Cog)	Baseline and 2 weeks	The changes in Alzheimers Disease Assessment Scale Cognitive section (ADAS-Cog) will constitute the major research outcome measure used to assess response to transcranial magnetic stimulation (TMS). The ADAS-COG scale tests orientation, language, structure, use of ideas, immediate recall of words and word re-recognition, and consists of 11 questions out of a possible 70 points, with the higher the score the more cognitively impaired.
Secondary	Mini Mental State Examination (MMSE)	Baseline and 2 weeks	The changes in MMSE will constitute the primary research outcome. The full name of MMSE is mini-mental state examination, and the scale consists of 30 subject, include the following seven aspects: time orientation, place orientation, immediate memory, attention and calculation, delay memory, language, visual space. One point is awarded for each question correctly answered during MMSE evaluation. If subject give the wrong answer or don't know answer he/she awarded 0 score, scope of scale score of 0 to 30 points. The higher the score, the better. In this study, changes in MMSE scores before and after treatment were used as secondary outcome measure.
Secondary	Montreal Cognitive Assessment (MoCA)	Baseline and 2 weeks	The changes in MoCA will be used to assess the response to TMS. MoCA was developed by Nasreddine et al. based on clinical experience and reference to the MMSE cognitive items and scores, and the final version was finalized in November 2004. The investigators adopted a localized version (Mandarin version#includes 2 alternative versions) in line with the Chinese cultural background. It includes 11 inspection items in 8 cognitive fields, including visual structure skills, executive function, naming, attention and calculation, language, abstract thinking, memory, and orientation. The normal score range from 26 to 30. Anyone who has been education for less than 12 years will need to add one point to his final score. The final score of the higher the better.
Secondary	Digital Span Test; Forward and Backward (DST)	Baseline and 2 weeks	The changes in DST will constitute the secondary research outcome. Digital span test (DST) was commonly used to evaluate attention ability and instantaneous memory ability. There are two types of test: forward (0-14) and backward (0-13). In the forward test, the subjects were asked to retell the the digits immediately after hearing it untilthey could not be repeated correctly. In backward test, the subjects were asked to repeat a set of numbers in reverse order until they could not be repeated correctly. The length of the last set of Numbers correctly repeated by the subjects was the final score, forward and backward are counted separately. The higher the score, the better.
Secondary	Hamilton Depression Scale (HAMD)	Baseline and 2 weeks	Hamilton Depression Scale (HAMD) compiled by Hamilton in 1960, is the most common clinical to assess Depression Scale. In this study, we selected the HAMD version with 17 questions. Subjects were assessed for their depression in the past week. Each question scored between 0 and 4 points. Higher scores indicate more depressive symptoms. The severity of the disease and the therapeutic effect can be evaluated after treatment.
Secondary	Hamilton Anxiety Scale (HAMA)	Baseline and 2 weeks	Hamilton Anxiety Scale (HAMA) was compiled by Hamilton in 1959. It was one of the most commonly used scales in psychiatric clinic, including 14 items. It is often used in clinical diagnosis and degree classification of anxiety disorder. The subjects were assessed for their anxiety in the past week. Each question scored between 0 and 4 points. The higher the score, the more symptoms of anxiety.
Secondary	Neuropsychiatric Inventory (NPI)	Baseline and 2 weeks	The Neuropsychology Scale (NPI) evaluates 12 neuropsychiatric disorders which included 10 neuropsychiatric symptoms and 2 autonomic neurological symptoms based on the caregiver's perception of the patient's behavior and the perceived distress. Each item was evaluated for its occurrence frequency (1-4 points) and severity (1-3 points). The frequency and severity were multiplied to obtain the score (0-12 points) of each item.The patient's assessment rating ranges from 0 to 144, and the caregiver's distress rating score is 0 to 60. The lower the score, the lighter the symptoms.
Secondary	Judgment of line Judgment of line orientation test (JLOT)	Baseline and 2 weeks	The JLOT test was determined by Benton et al. in 1994. There are two versions of H and V. The difference is that the order in which the pictures are presented is different. Each version contains 35 images, of which the official test consists of 30 images, and the other 5 images are for the participants to learn. The final score is the correct number of subjects to answer, the full score is 30 points, the higher the score, the better the space perception ability of the subject.
Secondary	Hooper visual organization test (HVOT)	Baseline and 2 weeks	HVOT is a cognitive test used to evaluate the perceived structure of the subject. It consists of 30 items (1 point each question) and the total score is 30 points. The final score is the correct number of subjects to answer, the full score is 30 points. The higher the score, the better the space perception ability of the subject.
Secondary	The Stroop color word test	Baseline and 2 weeks	The Stroop color word test was developed by Stroop in 1935 and is used to evaluate the attention function of the subject. The subject is required to correctly read the target color on the stimulus card and record the completion time. The final completion time is the score of the participant. The shorter the time used, the better the performance of the subjects.
Secondary	EEG	Baseline and 2 weeks	EEG data were obtained from each subject based on 64 electrode locations of the International 10-20 system (sampling frequency 1000Hz).
Secondary	Logic Memory Test (LMT)	Baseline and 2 weeks	The Logical Memory test, part of the Wechsler Memory Scale, primarily assesses an individual's verbal memory capabilities. The test involves presenting two brief stories to the subject, who is then asked to immediately recall and subsequently recall them after a delay. By comparing the immediate and delayed recall performance, the subtest evaluates both short-term and long-term memory retention.
Secondary	Pittsburgh Sleep Quality Index (PSQI)	Baseline and 2 weeks	The Pittsburgh Sleep Quality Index (PSQI) is a standardized tool used to assess individual sleep quality. It consists of 19 self-rated items that evaluate sleep quality, covering 7 aspects including sleep duration, efficiency, disturbances, and others. Each component is scored from 0 to 3, with higher scores indicating poorer sleep quality.

Source ClinicalTrials.govtrials-2026-11-12-0.4.0

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ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNone stated
NIH RePORTER's clinical studies and project filesPublic domain

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ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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