Trial · NCT07207304
Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes
NCT07207304, Not applicable, Completed, Iuliu Hatieganu University of Medicine and Pharmacy
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes. Trials, record NCT07207304. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07207304
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes
- NCT number
- NCT07207304
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 153 participants, actual
- Lead sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
- Conditions
- Hepato-cellular Carcinoma, Neutrophil Extracellular Trap Formation, Anesthesia, Lidocaine Infusion
- Interventions
Anesthesia, Anesthesia induction with TCI, sevoflurane anesthesia, Lidocaine Infusion, Intraoperative analgesia, Non-opioid analgesics, Morphine (+), Bispectral Index (BIS), Intraoperative mechanical ventilation, Blood sampling
- First posted
- 2025-10-03
- Last updated
- 2026-06-23
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Survival outcomes after hepatocellular carcinoma resection. | one year postoperatively | Patients will be followed for a period of one year to assess overall survival and progression-free survival. Follow-up will be conducted via direct contact, telephone, or e-mail. Information will be collected regarding the patient's general health status, disease progression, the presence and timing of tumor recurrence, as well as any hospitalizations occurring postoperatively, including the reason for medical consultation. Additionally, results from relevant investigations-such as computed tomography (CT), ultrasound, and blood tests-recommended by the treating surgeon or oncologist will be requested and reviewed. |
| Primary | NETosis quantification | Preoperatively and after 6 hours postoperatively | For each patient, 10 mL of blood will be collected from a peripheral vein both preoperatively and 6 hours postoperatively to determine the concentrations of MPO-DNA (myeloperoxidase-DNA complexes), H3Cit (citrullinated histone H3), and cfDNA (cell-free DNA). These biomarkers are closely associated with the formation of neutrophil extracellular traps (NETs). We aim to analyze the potential relationship between the dynamics of NETosis formation, the duration of anesthesia, and postoperative patient outcomes. |
| Secondary | Quantification of the inflammatory response | Preoperatively and at 6, 12, and 24 hours postoperatively | Samples will be collected for the analysis of inflammatory markers, C-reactive protein (CRP), total leukocyte count, blood glucose levels, and procalcitonin will be evaluated. In selected cases, interleukin levels (IL-6, IL-8, IL-10, and IL-17) will also be measured. We will analyze the relationship between the dynamics of classical inflammatory markers and NETosis across the four patient groups. |
| Secondary | Opioid use | In the first 24 hours postoperatively | We will evaluate the intraoperative and early postoperative opioid requirements by recording the total amount of opioids administered during surgery and in the first 24 hours postoperatively. In the initial analysis, we will compare the opioid consumption between patients who received continuous intravenous lidocaine infusion and those who did not, irrespective of the anesthetic technique used. Subsequently, we will assess potential differences in opioid requirements across all four study groups. |
| Secondary | Length of hospital stay | From the immediate postoperative period until discharge | We will analyze whether differences in the length of hospital stay are associated with perioperative factors such as the type of anesthesia administered, the total intraoperative and early postoperative opioid consumption, and specific surgical characteristics, including the extent of liver resection and intraoperative complications. Additionally, we will assess the impact of early postoperative events-such as the incidence of postoperative delirium, postoperative nausea and vomiting (PONV), impaired mobilization due to inadequate pain control, and opioid-related adverse effects-on prolonged hospitalization. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers7
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07207304
GET https://conductscience.org/api/trials/v1/NCT07207304/registered