Trial · NCT07212868
The Role of Glucagon in Glucose Metabolism in Humans With and Without Bariatric Surgery
NCT07212868, Phase 1, Recruiting, The University of Texas Health Science Center at San Antonio
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Role of Glucagon in Glucose Metabolism in Humans With and Without Bariatric Surgery. Trials, record NCT07212868. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07212868
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Role of Glucagon in Glucose Metabolism in Humans With and Without Bariatric Surgery
- NCT number
- NCT07212868
- Status
- Recruiting
- Phases
- Phase 1
- Enrollment
- 150 participants, estimated
- Lead sponsor
- The University of Texas Health Science Center at San Antonio
- Conditions
- Non-Diabetic
- Interventions
- REMD-477 versus Placebo, Exogenous glucagon versus saline infusion
- First posted
- 2025-10-08
- Last updated
- 2026-10-05
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Glycemic response to meal ingestion | 0 to 240 minutes | Changes in glucose response to meal ingestion occurred by administration of glucagon receptor antagonist (GRA). |
| Primary | Endogenous glucose production (EGP) during clamp studies | 0 to 240 minutes | Changes in EGP (measured by tracer technique) with and without glucagon infusion |
| Secondary | Prandial glucose kinetics | Baseline to 240 minutes | Glucose flux with and without GRA administration |
| Secondary | Plasma GLP-1, GIP, insulin and glucagon concentrations | 0 to 240 minutes | Changes in these outcomes following meal ingestion with and without GRA administration |
| Secondary | Glucose clearance and insulin and glucagon concentrations during clamp studies | 0 to 240 minutes | Outcomes with and without glucagon infusion |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R01DK141843 | Glucagon-mediated glycemic effect in humans with and without rerouted gut after bariatric surgery | SALEHI, MARZIEH | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER | NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES | 2025 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07212868
GET https://conductscience.org/api/trials/v1/NCT07212868/registered