Trial · NCT07216794
Small Trial of Alendronate Impact on the Reservoir of HIV
NCT07216794, Phase 2, Recruiting, National Institute of Allergy and Infectious Diseases (NIAID)
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Small Trial of Alendronate Impact on the Reservoir of HIV. Trials, record NCT07216794. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07216794
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Small Trial of Alendronate Impact on the Reservoir of HIV
- NCT number
- NCT07216794
- Status
- Recruiting
- Phases
- Phase 2
- Enrollment
- 30 participants, estimated
- Lead sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
- Conditions
- HIV
- Interventions
- Alendronate, Placebo
- First posted
- 2025-10-15
- Last updated
- 2026-10-05
Source ClinicalTrials.gov
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in intact HIV-1 deoxyribonucleic acid (DNA) copies by the Intact Proviral DNA Assay (IPDA) in peripheral blood | Baseline to week 24 | |
| Secondary | Amount of ALN excreted after initial dose of ALN | Over 24 hours | |
| Secondary | Peripheral blood CD4+ cell-associated (CA) HIV-1 RNA levels (unspliced and multiply spliced species by quantitative polymerase chain reaction [qPCR]) | At Baseline and Weeks 12, 24 and 32 | |
| Secondary | Number of plasma HIV-1 RNA copies [by single copy assay (SCA)] | At Baseline and Weeks 12, 24 and 32 | |
| Secondary | HIV RNA in the GI tract (RNA scope and spatial immunophenotyping in sigmoidoscopy samples) | Pre-intervention and Weeks 22-24 | |
| Secondary | Number of intact HIV-1 DNA copies by the IPDA in peripheral blood | Weeks 2, 12, and 32 | |
| Secondary | HIV DNA in the GI CD4+ and Vdelta1 (Vd1) T cells (DNA scope in sigmoidoscopy samples) | Pre-intervention and Weeks 22-24 | |
| Secondary | Peripheral blood CD4+ cell-associated (CA) HIV-1 RNA levels (unspliced and multiply spliced species by qPCR) | At Baseline and Weeks 1 and 2 | |
| Secondary | Number of plasma HIV-1 RNA copies (by SCA) | At Baseline and Weeks 1 and 2 | |
| Secondary | Frequency of αβ CD8+ cells by flow cytometry | Pre-intervention and Weeks 1, 12, 24, and 32 |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07216794
GET https://conductscience.org/api/trials/v1/NCT07216794/registered