Trial · NCT07221799
OER Glibenclamide for Neuropathic Pain in Multiple Sclerosis
NCT07221799, Phase 1, Not yet recruiting, University of Maryland, Baltimore
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. OER Glibenclamide for Neuropathic Pain in Multiple Sclerosis. Trials, record NCT07221799. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07221799
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- OER Glibenclamide for Neuropathic Pain in Multiple Sclerosis
- NCT number
- NCT07221799
- Status
- Not yet recruiting
- Phases
- Phase 1
- Enrollment
- 10 participants, estimated
- Lead sponsor
- University of Maryland, Baltimore
- Conditions
- Multiple Sclerosis, Neuropathic Pain
- Interventions
- glibenclamide, Placebo
- First posted
- 2025-10-28
- Last updated
- 2025-10-28
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Cmax | over 10 hours | maximum concentration |
| Primary | Safety | Through week 13 | Full reporting of any adverse events on study drug |
| Primary | Cmin | Over 10 hours | Minimum concentration |
| Primary | AUC | 10 hours | Area under curve |
| Primary | tmax | 10 hours | time to maximum concentration |
| Primary | t 1/2 | 10 hours | time to 1/2 maximum concentration |
| Primary | blood glucose | 10 hours | blood glucose during 10 hour pharmacokinetic measurements |
| Secondary | Change in PROMIS Neuropathic Pain Scale Score | Through week 13 | The questionnaire uses a standard T-score metric, with a mean of 50 and a standard deviation of 10 for a relevant reference population (often the US general population). Higher scores indicate a greater level of neuropathic pain qualities. |
| Secondary | Change in the PROMISE Pain Interference Score | Through week 13 | The PROMIS Pain Interference (PROMIS-PI) scale is a patient-reported outcome measure that assesses how pain affects daily life, including physical, mental, and social activities, as well as sleep and enjoyment. Scores are typically presented on a T-score metric, where 50 is the U.S. general population mean, with higher scores indicating greater pain interference. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07221799
GET https://conductscience.org/api/trials/v1/NCT07221799/registered