Trial · NCT07249164
Dexmedetomidine Medication Records and Delirium After Coronary Artery Bypass Grafting
NCT07249164, Completed, China Medical University Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Dexmedetomidine Medication Records and Delirium After Coronary Artery Bypass Grafting. Trials, record NCT07249164. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07249164
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Dexmedetomidine Medication Records and Delirium After Coronary Artery Bypass Grafting
- NCT number
- NCT07249164
- Status
- Completed
- Enrollment
- 343,112 participants, actual
- Lead sponsor
- China Medical University Hospital
- Conditions
- Delirium, Cardiac Surgical Procedures, Coronary Artery Bypass Graft (CABG), Valve Surgery, Postoperative Complications
- Interventions
- Dexmedetomidine, No dexmedetomidine medication record in the specified window
- First posted
- 2025-11-25
- Last updated
- 2026-11-12
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | First recorded code-defined delirium or disorientation during days 1-30 after the index procedure | Day 1 through Day 30 after the index procedure | Time to the first qualifying ICD-10-CM R41.0 or F05 record within the window. R41.0 includes disorientation; this is a code-defined outcome without bedside delirium assessment or individual adjudication. The CABG-coded population is primary and the valve-coded population exploratory. Patients with either code on or before day 0 in all available history are excluded before matching. The outcome-level prior-window exclusion is OFF. Analysis uses the two-sided log-rank test, Kaplan-Meier window-end failure estimates and complementary hazard ratios, subject to the documented censoring and proportionality limitations. The day-1 start is not a verified survival landmark. |
| Secondary | All-cause mortality during days 0-30 after the index procedure | Day 0 through Day 30 after the index procedure | Time to a dated death record using the TriNetX Deceased outcome. Death is the event for this endpoint. The data are not assumed to constitute a complete national death registry. Outcome-level prior-window exclusion is OFF. This is one of the eight inferential secondary endpoints in the CABG population. |
| Secondary | Code-defined acute kidney injury during days 0-30 | Day 0 through Day 30 after the index procedure | Time to the first qualifying ICD-10-CM N17 record, including applicable descendant codes, within the window. No endpoint-specific exclusion of prior N17 records is applied; this describes a recorded outcome, not necessarily newly occurring disease. Dialysis codes are not treated as acute kidney injury. This replaces the earlier acute-kidney-injury/dialysis composite and is one of the eight inferential secondary endpoints. |
| Secondary | Code-defined pneumonia during days 0-30 | Day 0 through Day 30 after the index procedure | Time to the first qualifying record of ICD-10-CM J13, J14, J15, J16, J17 or J18, or ICD-9-CM 483, within the window. No endpoint-specific exclusion of prior pneumonia records is applied. The outcome does not establish microbiological confirmation or newly occurring disease. This is one of the eight inferential secondary endpoints. |
| Secondary | Code-defined sepsis during days 0-30 | Day 0 through Day 30 after the index procedure | Time to the first qualifying ICD-10-CM A40 or A41 record within the window. No endpoint-specific exclusion of prior sepsis records is applied. This is a recorded-code outcome, not necessarily newly occurring sepsis, and is one of the eight inferential secondary endpoints. |
| Secondary | Blood transfusion, haemorrhage-related diagnosis or thoracic exploration code during days 0-30 | Day 0 through Day 30 after the index procedure | Any qualifying ICD-10-CM I97.410, I97.411, I97.610, I97.611 or D62 record, or SNOMED CT 116863004, 288170000, 301842006, 175190002, 26337002 or 77202008 record, during the analysis window, without endpoint-specific exclusion of prior qualifying records. The retained components include blood transfusion, haemorrhage-related diagnoses and thoracic, pericardial or mediastinal exploration. Exploration codes do not establish bleeding, a postoperative indication or re-operation. This heterogeneous code-defined composite is not major bleeding and does not establish an adjudicated bleeding severity grade. CPT 35820 is not included. This is one of the eight inferential secondary endpoints in the primary CABG comparison. |
| Secondary | Code-defined myocardial infarction during days 0-30 | Day 0 through Day 30 after the index procedure | Time to the first qualifying ICD-10-CM I21 or I22 record within the window. No endpoint-specific exclusion of prior myocardial infarction records is applied. This is a recorded-code outcome, not necessarily a new myocardial infarction, and is one of the eight inferential secondary endpoints. |
| Secondary | Code-defined ischaemic stroke or transient ischaemic attack during days 0-30 | Day 0 through Day 30 after the index procedure | Time to the first qualifying ICD-10-CM I63 or G45 record within the window. No endpoint-specific exclusion of prior stroke or transient ischaemic attack records is applied. This is a recorded-code outcome, not necessarily newly occurring disease, and is one of the eight inferential secondary endpoints. |
| Secondary | Code-defined atrial fibrillation during days 0-30 | Day 0 through Day 30 after the index procedure | Time to the first qualifying ICD-10-CM I48.0, I48.1 or I48.91 record within the window. No endpoint-specific exclusion of prior atrial fibrillation records is applied. The definition is limited to this specified code set and does not establish new-onset atrial fibrillation. This is one of the eight inferential secondary endpoints. |
| Secondary | Proportion of patients with respiratory ventilation coded as greater than 96 consecutive hours | Day 0 through Day 30 after the index procedure | Number and proportion of patients with at least one ICD-10-PCS 5A1955Z record during days 0-30. The code denotes respiratory ventilation greater than 96 consecutive hours, but its recorded date does not establish intubation onset or when 96 hours was reached. This explicitly replaces the previously registered days 4-30 window. Use this outcome batch's analysed denominator; prior-window exclusion is OFF. This is a descriptive recorded-code proportion, not a censoring-adjusted risk. No ventilation Kaplan-Meier or Cox analysis is performed. Comparative statistics generated automatically with the native patient-count output are preserved but are not interpreted as inferential study results or included in multiplicity adjustment. |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers3
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07249164
GET https://conductscience.org/api/trials/v1/NCT07249164/registered