Trial · NCT07249840
Ropeginterferon for High Risk JAK2 Clonal Hematopoiesis
NCT07249840, Phase 1, Recruiting, Brigham and Women's Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Ropeginterferon for High Risk JAK2 Clonal Hematopoiesis. Trials, record NCT07249840. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07249840
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Ropeginterferon for High Risk JAK2 Clonal Hematopoiesis
- NCT number
- NCT07249840
- Status
- Recruiting
- Phases
- Phase 1
- Enrollment
- 12 participants, estimated
- Lead sponsor
- Brigham and Women's Hospital
- Conditions
- JAK2 Mutation
- Interventions
- Ropeginterferon
- First posted
- 2025-11-25
- Last updated
- 2026-07-28
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of patients consented and enrolled within 2 years of study opening | 2 years | Primary outcome is feasibility, or feasibility of enrolling 12 patients with high-risk JAK2 clonal hematopoiesis onto a clinical trial with ropeginterferon treatment within 2 years of study opening. |
| Primary | Number of participants with treatment-related adverse events as assessed by CTCAE v5.0 | 2 years | Safety and tolerability of ropeginterferon in patients with JAK2 clonal hematopoiesis and high-risk features. |
| Secondary | Number of patients with decrease of JAK2 V617F variant allele fraction to undetectable levels if baseline VAF was <10% or decrease of JAK2 V617F VAF by at least 50% if baseline VAF was >10% | 2 years | Molecular response |
| Secondary | Rates of arterial and venous thrombosis | 2 years | |
| Secondary | Rates of bleeding | 2 years | |
| Secondary | Patient reported quality of life as measured by the Patient's Impression of Global Change (PGIC) and Patient-Reported Outcomes Measurement Information System 29-item Health Profile (PROMIS-29) | 2 years | |
| Secondary | Rates of progression to overt MPN | 2 years |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07249840
GET https://conductscience.org/api/trials/v1/NCT07249840/registered