Trial · NCT07275359
Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations
NCT07275359, Phase 1, Not yet recruiting, Duke University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations. Trials, record NCT07275359. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07275359
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations
- NCT number
- NCT07275359
- Status
- Not yet recruiting
- Phases
- Phase 1
- Enrollment
- 45 participants, estimated
- Lead sponsor
- Duke University
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD)
- Interventions
- Metformin
- First posted
- 2025-12-10
- Last updated
- 2026-11-03
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Determine feasibility of metformin administration in older persons with COPD without diabetes | 6 months | Enroll and retain ≥ 30 (66%) participants through 6 months study period |
| Primary | Determine acceptability of metformin administration in older persons with COPD without diabetes | 6 months | ≥70% completion of daily symptom diaries \& weekly adherence logs |
| Primary | Determine safety of metformin administration in older persons with COPD without diabetes | 6 months | ≥90% of the blood glucose levels, renal and hepatic function will be within normal limits\*; All lactate levels will be normal |
| Primary | Determine tolerability of metformin administration in older persons with COPD without diabetes | 6 months | Adverse events and Serious adverse events |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| K76AG095138 | Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations (INSPIRE-COPD-E). | MOSHER, CHRISTOPHER | DUKE UNIVERSITY | NATIONAL INSTITUTE ON AGING | 2025 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07275359
GET https://conductscience.org/api/trials/v1/NCT07275359/registered