Trial · NCT07284745
A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism
NCT07284745, Phase 3, Recruiting, Bristol-Myers Squibb
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism. Trials, record NCT07284745. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07284745
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism
- NCT number
- NCT07284745
- Status
- Recruiting
- Phases
- Phase 3
- Enrollment
- 176 participants, estimated
- Lead sponsor
- Bristol-Myers Squibb
- Conditions
- Irritability Associated With Autism Spectrum Disorder
- Interventions
- KarXT, KarX-EC, KarXT + KarX-EC Matching Placebo
- First posted
- 2025-12-16
- Last updated
- 2026-11-10
Source ClinicalTrials.gov
Registered outcomes15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change From Baseline in the Aberrant Behavior Checklist Irritability (ABC-I) Score at Week 8 | Week 8 | |
| Secondary | Change From Baseline in the Clinical Global Impression-Severity (CGI-S) Score at Week 8 | Week 8 | |
| Secondary | Clinical Global Impression-Improvement (CGI-I) Score at Week 8 | Week 8 | |
| Secondary | Number of Participants With ABC-I Response at Week 8 | Week 8 | |
| Secondary | Change From Baseline on the ABC Subscale for Social Withdrawal at Week 8 | Week 8 | |
| Secondary | Change From Baseline on the Stereotypic Behavior Subscale at Week 8 | Week 8 | |
| Secondary | Change From Baseline on the Hyperactivity/Noncompliance Subscale at Week 8 | Week 8 | |
| Secondary | Change From Baseline on the Inappropriate Speech Subscale at Week 8 | Week 8 | |
| Secondary | Number of Participants With Procholinergic Symptoms | Up to approximately 12 weeks | |
| Secondary | Number of Participants With Anticholinergic Symptoms | Up to approximately 12 weeks |
1 to 10 of 15Source ClinicalTrials.gov
See all 15 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07284745
GET https://conductscience.org/api/trials/v1/NCT07284745/registered