Trial · NCT07292259
Combination of Thalidomide and Hydroxyuria in Transfusion Dependent Thalasemmia
NCT07292259, Phase 2, Completed, Pakistan Blood and Marrow Transplant (PBMT) Group
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Combination of Thalidomide and Hydroxyuria in Transfusion Dependent Thalasemmia. Trials, record NCT07292259. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07292259
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Combination of Thalidomide and Hydroxyuria in Transfusion Dependent Thalasemmia
- NCT number
- NCT07292259
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 100 participants, actual
- Lead sponsor
- Pakistan Blood and Marrow Transplant (PBMT) Group
- Conditions
- Transfusion Dependent Beta Thalassemia
- Interventions
- ADDITION OF THALIDOMIDE AND HYDROXYUREA
- First posted
- 2025-12-18
- Last updated
- 2026-05-05
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of Red Blood Cell Transfusions after starting a combination of Thalidomide and hydroxyurea | 01 Year | The frequency of Red Blood cell transfusions before the start of intervention will be noted. At 03 months, 06 months, and 12 months of intervention (Thalidomide and hydroxyurea) number of Red Blood cell transfusions will be documented. |
| Secondary | To document the spectrum and frequency of significant adverse drug reactions. | 01 Year | Monitoring and recording any adverse effects associated with thalidomide and hydroxyurea therapy at Day-90, Day-180, and Day-365. Patients will be contacted on the telephone weekly by the drug safety monitoring board and will be screened for any side effects of the intervention. |
| Secondary | To assess changes in spleen size during the intervention. | 01 Year | Assessment of spleen size in centimeters at Day-01, Day-90, Day-180, and Day-365 of intervention. |
| Secondary | Monitoring of Serum Ferritin levels in ng/ml during the time of intervention. | 01 Year | Measurement of Serum Ferritin Levels in ng/ml at Day-01, Day-90, Day-180, and Day-365. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers5
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07292259
GET https://conductscience.org/api/trials/v1/NCT07292259/registered