In Vitro Fertilization (IVF) and Prenatal Effects Independent of Genetics
NCT07296107, Recruiting, Columbia University
Trial 9
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | In Vitro Fertilization (IVF) and Prenatal Effects Independent of Genetics | ClinicalTrials.gov |
| NCT number | NCT07296107 | ClinicalTrials.gov |
| Status | Recruiting | ClinicalTrials.gov |
| Enrollment | 360 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Columbia University | ClinicalTrials.gov |
| Conditions | Maternal Distress, Child Development | ClinicalTrials.gov |
| Interventions | Prenatal maternal psychosocial and biological assessment protocol | ClinicalTrials.gov |
| First posted | 2025-12-22 | ClinicalTrials.gov |
| Last updated | 2026-07-07 | ClinicalTrials.gov |
Registered outcomes 6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in fetal heart rate (FHR) | At Pregnancy Session 2 (approximately 34-36 weeks of pregnancy) | This is to measure 3rd trimester fetal heart rate (FHR) reactivity. Change in FHR in response to maternal response to the Stroop task, indicating greater fetal autonomic response associated with maternal distress. Units: Beats per minute (bpm). Greater FHR indicates higher stress. | ClinicalTrials.gov |
| Primary | Standard deviation of fetal heart rate | At Pregnancy Session 2 (approximately 34-36 weeks of pregnancy) | This is to measure fetal heart rate (FHR) variability, reflecting less vagal modulation of the heart associated with maternal distress. Units: Standard deviation of beats per minute. Lesser standard deviation (SD) indicates lower stress. | ClinicalTrials.gov |
| Primary | Cross correlation of fetal movement and heart rate change | At Pregnancy Session 2 (approximately 34-36 weeks of pregnancy) | This is to measure fetal heart rate (FHR)-movement coupling, reflecting central nervous system regulation. Units: Cross correlation value. Lower value indicates lower coupling. | ClinicalTrials.gov |
| Primary | Average percent DNA methylation of the FKBP5 gene in placental tissue | At delivery (approximately 37-40 weeks) | This is to measure FKBP5 DNA Methylation. Units: proportion of methylated vs unmethylated. Greater percent indicates higher methylation. | ClinicalTrials.gov |
| Primary | Average percent DNA methylation of the HSD11B2 gene in placental tissue | At delivery (approximately 37-40 weeks) | This is to measure HSD11B2 DNA Methylation. Units: proportion of methylated vs unmethylated. Greater percent indicates higher methylation. | ClinicalTrials.gov |
| Primary | Relative expression of key pro-inflammatory markers in placental tissue | At delivery (approximately 37-40 weeks) | This is to measure expression of Pro-Inflammatory Placental Genes. Units: Gene expression. Greater value indicates greater expression. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 1
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Primary outcome | ConductCognition |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.3.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 4a570df2e7274cee2d4fa2959402fab41880e2cd412e4b590390035fbea69391 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
Release trials-2026-11-12-0.3.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.