Trial · NCT07346196
A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck
NCT07346196, Phase 2, Not yet recruiting, University of Chicago
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck. Trials, record NCT07346196. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07346196
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck
- NCT number
- NCT07346196
- Status
- Not yet recruiting
- Phases
- Phase 2
- Enrollment
- 90 participants, estimated
- Lead sponsor
- University of Chicago
- Conditions
- Squamous Cell Carcinoma
- Interventions
- Cemiplimab, Fianlimab, Carboplatin, Paclitaxel, Radiation
- First posted
- 2026-01-16
- Last updated
- 2026-01-20
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Overall Response Rate | 9 weeks | To assess the overall response rate (ORR) of induction cemiplimab and chemotherapy, with or without fianlimab in patients with locoregionally advanced squamous cell carcinoma of the head and neck. ORR will be measured and compared between the two treatment groups using a pick-the-winner design. |
| Secondary | Assess survival and progression based on RECIST | 2 years | Assess overall survival and progression free survival outcomes of patients receiving induction cemiplimab and chemotherapy with or without fianlimab followed by chemoradiation. |
| Secondary | Using RECIST to assess disease control | 24 months | Assess disease control in patients receiving induction cemiplimab and chemotherapy with or without fianlimab followed by chemoradiation. |
| Secondary | Assess acute and long-term/late toxicities using RECIST | 1 month, 3 months, and 1-year post-chemoradiation | Assess acute and long-term/late toxicities of induction cemiplimab and chemotherapy with or without fianlimab followed by chemoradiation. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07346196
GET https://conductscience.org/api/trials/v1/NCT07346196/registered