Trial · NCT07356778
A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy
NCT07356778, Phase 4, Recruiting, Kazuya Hosokawa
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy. Trials, record NCT07356778. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07356778
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy
- NCT number
- NCT07356778
- Status
- Recruiting
- Phases
- Phase 4
- Enrollment
- 36 participants, estimated
- Lead sponsor
- Kazuya Hosokawa
- Conditions
- Eisenmenger Syndrome, Pulmonary Arterial Hypertension of Congenital Heart Disease
- Interventions
- Sotatercept, vasodilator-based PAH therapy
- First posted
- 2026-01-21
- Last updated
- 2026-01-21
Source ClinicalTrials.gov
Registered outcomes15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in 6-minute walk distance at 24 weeks from baseline | 24 weeks | |
| Secondary | Mortality or lung transplantation | 24 weeks | |
| Secondary | PH-related hospitalisation or initiation of parenteral prostacyclin | 24 weeks | |
| Secondary | Change in WHO functional class at 24-week from baseline | 24 weeks | A higher score indicates more severe symptom |
| Secondary | Change in NT-pro BNP at 24-week from baseline | 24 weeks | |
| Secondary | Change in emPHasis-10 at 24-week from baseline | 24 weeks | A higher score indicates more severe symptom |
| Other | PAH specific genetic test | 0 week | |
| Other | Changes in blood pressure (systolic and diastolic) | 0, 12, 24 weeks | Office resting BP |
| Other | Changes in pulse rate | 0, 12, 24 weeks | bpm |
| Other | Changes in oxygen saturation | 0, 12, 24 weeks | Pulse Oxygen Saturation (Office, Resting) |
1 to 10 of 15Source ClinicalTrials.gov
See all 15 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 41819579 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07356778
GET https://conductscience.org/api/trials/v1/NCT07356778/registered