Trial · NCT07356973
Irinotecan-ChemoSeed in Surgically Resectable Glioblastoma
NCT07356973, Phase 2, Recruiting, CRISM Therapeutics LTD
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Irinotecan-ChemoSeed in Surgically Resectable Glioblastoma. Trials, record NCT07356973. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07356973
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Irinotecan-ChemoSeed in Surgically Resectable Glioblastoma
- NCT number
- NCT07356973
- Status
- Recruiting
- Phases
- Phase 2
- Enrollment
- 147 participants, estimated
- Lead sponsor
- CRISM Therapeutics LTD
- Conditions
- Glioblastoma
- Interventions
- irinotecan-ChemoSeed implementation into the resection cavity after surgical resection of GBM
- First posted
- 2026-01-21
- Last updated
- 2026-11-09
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Part 1 To determine the optimal Dose of Irinotecan (RP2D) to be administered for Part 2. | 13 months | |
| Primary | Part 2. Determination Of Progression Free Survival (PFS) to demonstrate the superiority of irinotecan-ChemoSeed compared to concurrent to SoC treatment | 39 months | To demonstrate superiority of irinotecan-ChemoSeed concurrent to SoC treatment and administered into the resection margin following maximal safe surgical resection relative to SoC treatment alone, by assessment of progression-free survival (PFS). |
| Secondary | Overall Response Rate (ORR) | 6 months from recruitment | ORR at 6 months by MRI using RANO 2.0 criteria, by independent central review and by investigator assessment. |
| Secondary | Disease Control Rate (DCR) | 12 months from recruitment | DCR at 12 months by MRI using RANO 2.0 by independent central review and investigator assessment. |
| Secondary | Overall Survival | 39 months | Comparison of Median OS for control and treated arms |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07356973
GET https://conductscience.org/api/trials/v1/NCT07356973/registered