Trial · NCT07364344
Safety and Preliminary Efficacy of Hibernation-Like Therapy (Chlorpromazine and Promethazine) in Patients With Acute Ischemic Stroke (AIS) Eligible for Reperfusion Therapy.
NCT07364344, Not applicable, Not yet recruiting, Ji Xunming,MD,PhD
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Safety and Preliminary Efficacy of Hibernation-Like Therapy (Chlorpromazine and Promethazine) in Patients With Acute Ischemic Stroke (AIS) Eligible for Reperfusion Therapy. Trials, record NCT07364344. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07364344
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Safety and Preliminary Efficacy of Hibernation-Like Therapy (Chlorpromazine and Promethazine) in Patients With Acute Ischemic Stroke (AIS) Eligible for Reperfusion Therapy.
- NCT number
- NCT07364344
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 57 participants, estimated
- Lead sponsor
- Ji Xunming,MD,PhD
- Conditions
- Acute Ischemic Stroke
- Interventions
- Hibernation-like Therapy (Chlorpromazine and Promethazine, C+P)
- First posted
- 2026-01-23
- Last updated
- 2026-01-23
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Observation of DLT and MTD across different C+P dose cohorts to determine the RP2D. | From the initiation of Hibernation-Like Therapy until 7 days after treatment. | |
| Secondary | Change in cerebral infarct volume (mL) at 48 ±12 hours post-treatment compared to pre-treatment. | From the start of Hibernation-Like Therapy to 48±12 hours after treatment. | |
| Secondary | Change in the National Institutes of Health Stroke Scale (NIHSS) score at 24 hours post-treatment compared to baseline. | From the start of Hibernation-Like Therapy to 24 hours after treatment. | |
| Secondary | Magnitude of vital sign changes (absolute differences in temperature, BP, and respiration post-C+P vs. baseline). | From the initiation of Hibernation-Like Therapy until 7 days after treatment. | |
| Other | Ratio of specific metabolite downregulation after 3 hours of C+P therapy versus baseline (serum enrichment analysis). | From the start of Hibernation-Like Therapy to 3 hours after treatment. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers10
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07364344
GET https://conductscience.org/api/trials/v1/NCT07364344/registered