Trial · NCT07385898
Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer
NCT07385898, Not applicable, Completed, The Second Affiliated Hospital of Chongqing Medical University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer. Trials, record NCT07385898. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07385898
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer
- NCT number
- NCT07385898
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 64 participants, actual
- Lead sponsor
- The Second Affiliated Hospital of Chongqing Medical University
- Conditions
- Rectal Tumors, Tumor of Sigmoid Colon, Lung Injury, Surgery, Laparoscopic, Dexmedetomidine
- Interventions
- Dexmedetomidine, Normal saline
- First posted
- 2026-02-04
- Last updated
- 2026-02-04
Source ClinicalTrials.gov
Registered outcomes22
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | oxygenation index | When patients enter the operation room (T0), 5 minutes after completion of pneumoperitoneum and trendelenburg position (T1), 30 (T2) and 60 (T3) minutes after trendelenburg position, when extubate the endotracheal tube (about 30 min postoperatively, T4) | oxygenation index is the ratio of partial pressure of O2 in arterial blood to fraction of inspired oxygen, namely PaO2/FiO2 ratio. |
| Secondary | PaCO2 | When patients enter the operation room (T0), 5 minutes after completion of pneumoperitoneum and trendelenburg position (T1), 30 (T2) and 60 (T3) minutes after trendelenburg position, when extubate the endotracheal tube (about 30 min postoperatively, T4) | arterial carbon dioxide pressure assessed by arterial blood gas measurement. |
| Secondary | EtCO2 | 5 minutes after establishment of pneumoperitoneum and trendelenburg position (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3) | end-tidal carbon dioxide pressure assessed by arterial blood gas measurement. |
| Secondary | Pplat | 5 minutes after establishment of pneumoperitoneum and trendelenburg position (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3) | plateau pressure (Pplat) is the end-inspiratory airway pressure and is measured just after airflow has ceased, which is displayed automatically on the anesthesia machine. |
| Secondary | Ppeak | 5 minutes after establishment of pneumoperitoneum and trendelenburg position (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3) | peak airway pressure is the highest pressure measured during the respiratory cycle and is a function of both the resistance of the airways and the compliance of the respiratory system, which is displayed automatically on the anesthesia machine. |
| Secondary | lung compliance | 5 minutes after establishment of pneumoperitoneum and trendelenburg position (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3) | lung compliance is defined as the change in lung volume for a unit change in transalveolar pressure, which is displayed automatically on the anesthesia machine. |
| Secondary | Vd/Vt | 5 minutes after establishment of pneumoperitoneum and trendelenburg position (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3) | Vd/Vt represents dead space ventilation, which is the volume of ventilated air that does not participate in gas exchange. Vd/Vt = 1.14 × (PaCO2-EtCO2) / PaCO2-0.005. |
| Secondary | Qs/Qt | When patients enter the operation room (T0), 5 minutes after completion of pneumoperitoneum and trendelenburg position (T1), 30 (T2) and 60 (T3) minutes after trendelenburg position, when extubate the endotracheal tube (about 30 min postoperatively, T4) | Qs/Qt is a measurement of pulmonary shunt. It describes the percentage of blood that reaches the left side of the heart without picking up oxygen. Qs/Qt = (CcO2 - CaO2) / (CcO2 - CvO2), where CcO2 = pulmonary end-capillary O2 content, same as alveolar O2 content, CaO2 = arterial O2 content, CvO2 = mixed venous O2 content. |
| Secondary | PA-aO2 | When patients enter the operation room (T0), 5 minutes after completion of pneumoperitoneum and trendelenburg position (T1), 30 (T2) and 60 (T3) minutes after trendelenburg position, when extubate the endotracheal tube (about 30 min postoperatively, T4) | alveolar-arterial oxygen gradient measures the difference between the oxygen concentration in the alveoli and arterial system, which can be obtained from the arterial blood gas measurement. |
| Secondary | SPO2 | When patients enter the operation room (T0), 5 minutes after trendelenburg position (T1), 30 (T2) and 60 (T3) minutes after trendelenburg position, when extubate the endotracheal tube (about 30 min postoperatively, T4), postoperative day 1-3 | oxygen saturation refers to the amount of oxygen bound to hemoglobin in arterial blood. |
1 to 10 of 22Source ClinicalTrials.gov
See all 22 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers7
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07385898
GET https://conductscience.org/api/trials/v1/NCT07385898/registered?page=2