Trial · NCT07388407
Pharmacogenetics of Leflunomide in the Management of Rheumatoid Arthritis
NCT07388407, Recruiting, Foundation University Islamabad
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Pharmacogenetics of Leflunomide in the Management of Rheumatoid Arthritis. Trials, record NCT07388407. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07388407
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Pharmacogenetics of Leflunomide in the Management of Rheumatoid Arthritis
- NCT number
- NCT07388407
- Status
- Recruiting
- Enrollment
- 110 participants, estimated
- Lead sponsor
- Foundation University Islamabad
- Conditions
- Rhematoid Arthritis
- Interventions
- Study for the correlation of SNPs with efficacy and toxicity of Leflunomide in RA patients
- First posted
- 2026-02-05
- Last updated
- 2026-02-05
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | DAS Score Measurement | 2 years | The Disease Activity Score (DAS28) is calculated by assessing 28 tender/swollen joints, blood inflammatory markers (ESR or CRP), and patient global health (VAS), with scores \<2.6 indicating remission and \>5.1 indicating high disease activity. It is primarily computed using specialised calculators for Rheumatoid Arthritis. We will take this score at the start of leflunomide therapy, at three-month intervals and at 6 months. The significant outcome will be a 10% decrease from the baseline and will be correlated with the SNP identified. |
| Secondary | SNP identification in DHOD gene | 2 years | SNPs detected from the Sanger sequencing will be tabulated against the efficacy, which is the DAS score and visual pain analogue. A 10% decrease in the baseline score will be considered significant improvement. An increase in the adverse effects like deranged LFTs, an increase in vomiting, and alopecia will be measured using ANOVA. |
| Secondary | Measurement of Hepatotoxicity of Leflunomide | 2 years | Baseline liver function tests will be recorded and then repeated at 3- and 6-month intervals to correlate with the genetic basis. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers10
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07388407
GET https://conductscience.org/api/trials/v1/NCT07388407/registered