Trial · NCT07391566
LPM6690176 in Combination With Chemotherapy and Bevacizumab in Metastatic Colorectal Cancer Patients With RAS Mutation
NCT07391566, Phase 1, Phase 2, Not yet recruiting, Luye Pharma Group Ltd.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. LPM6690176 in Combination With Chemotherapy and Bevacizumab in Metastatic Colorectal Cancer Patients With RAS Mutation. Trials, record NCT07391566. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07391566
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- LPM6690176 in Combination With Chemotherapy and Bevacizumab in Metastatic Colorectal Cancer Patients With RAS Mutation
- NCT number
- NCT07391566
- Status
- Not yet recruiting
- Phases
- Phase 1, Phase 2
- Enrollment
- 99 participants, estimated
- Lead sponsor
- Luye Pharma Group Ltd.
- Conditions
- Metastatic Colorectal Cancer (mCRC)
- Interventions
- LPM6690176, Bevacizumab, FOLFIRI (5-Fluorouracil, Folinic acid, Irinotecan)
- First posted
- 2026-02-06
- Last updated
- 2026-02-06
Source ClinicalTrials.gov
Registered outcomes15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Phase Ib: Dose-limiting toxicities (DLTs) | From the first dose of study drug treatment through Cycle 1 (28 days) | |
| Primary | Phase Ib: Maximum tolerated dose (MTD) | From the first dose of study drug treatment through Cycle 1 (28 days) | |
| Primary | Phase 1b: Recommended Phase 2 Dose (RP2D) | From the first dose of study drug treatment through Cycle 1 (28 days) | |
| Primary | Phase 2: Overall response rate (ORR) | Approximately 2 years | |
| Secondary | Phase 1b: Overall response rate (ORR) | Approximately 2 years | |
| Secondary | Duration of response (DOR) | Approximately 2 years | |
| Secondary | Disease control rate (DCR) | Approximately 2 years | |
| Secondary | Progression-free survival (PFS) | Approximately 2 years | |
| Secondary | Overall survival (OS) | Approximately 2 years | |
| Secondary | Maximum plasma concentration (Cmax) | From Pre-dose of Cycle 1 Day 1 and up to Cycle 1 Day 9 (Approximately 10 days, each cycle is 28 days) |
1 to 10 of 15Source ClinicalTrials.gov
See all 15 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07391566
GET https://conductscience.org/api/trials/v1/NCT07391566/registered