Trial · NCT07424183
T4/T3 Therapy in Hypothyroidism
NCT07424183, Phase 2, Not yet recruiting, University of Pennsylvania
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. T4/T3 Therapy in Hypothyroidism. Trials, record NCT07424183. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07424183
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- T4/T3 Therapy in Hypothyroidism
- NCT number
- NCT07424183
- Status
- Not yet recruiting
- Phases
- Phase 2
- Enrollment
- 60 participants, estimated
- Lead sponsor
- University of Pennsylvania
- Conditions
- Hypothyroidism Primary
- Interventions
- Liothyronine (L-T3), Levothyroxine Sodium (LT4) Tablets, Liothyronine (LT3) placebo
- First posted
- 2026-02-20
- Last updated
- 2026-08-20
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | ThyPRO Composite QOL Scale | 6 months | 22 items, scored 0-100, higher scores indicate worse status |
| Secondary | ThyPRO subscales | 6 months | ThyPRO hypothyroid symptoms and tiredness subscales, 4 items, scored 0-100, higher scores indicate worse status |
| Secondary | Thyroid Symptoms Questionnaire (TSQ) | 6 months | Thyroid symptoms scale, 12 items, score range 0-36, higher score indicates worse status |
| Secondary | Cognitive measures | Baseline and 6 months | NIH Toolbox Fluid Cognition Score, based around median of 100, higher scores indicate higher function |
| Secondary | Beck Depression Inventory | Baseline and 6 months | 21 items, range of 0-63, higher scores indicate more depressive symptoms |
| Secondary | Beck Anxiety Inventory | Baseline and 6 months | 21 items, range 0-63, higher scores indicate more anxiety |
| Secondary | Pittsburgh Sleep Quality Index | 6 months | 19 items, range of 0-21, higher scores indicate worse sleep |
| Secondary | Weight | 6 months | Kilograms |
| Secondary | LDL cholesterol | 6 months | Blood test, g/dL |
| Secondary | Serum c-telopeptide | 6 months | Blood test, pg/mL |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R01DK137207 | T4/T3 Therapy in Hypothyroidism | CAPPOLA, ANNE R | UNIVERSITY OF PENNSYLVANIA | NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES | 2024 to 2025 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07424183
GET https://conductscience.org/api/trials/v1/NCT07424183/registered