Trial · NCT07425600
Individualized Dose of Fibrinogen Following Cardiopulmonary Bypass
NCT07425600, Not yet recruiting, Centre Hospitalier Universitaire de Saint Etienne
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Individualized Dose of Fibrinogen Following Cardiopulmonary Bypass. Trials, record NCT07425600. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07425600
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Individualized Dose of Fibrinogen Following Cardiopulmonary Bypass
- NCT number
- NCT07425600
- Status
- Not yet recruiting
- Enrollment
- 150 participants, estimated
- Lead sponsor
- Centre Hospitalier Universitaire de Saint Etienne
- Conditions
- Fibrinogen Deficiency in Complex Cardiac Surgery
- Interventions
- Blood samples for PK
- First posted
- 2026-02-23
- Last updated
- 2026-04-22
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Characterize the sources of variability in plasma fibrinogen levels in response to administration of fibrinogen concentrate after cardiac surgery with cardiopulmonary bypass. | During surgery (day 0) (before transfusion then at 10min, 1 hour, 3 hours, 6 hours, 9 hours, 12 hours after transfusion) then at day 1, day 2, day 4 and day 6. | Measurement of blood samples using the Clauss technique |
| Secondary | Characterize the sources of variability in response to fibrinogen concentrate administration as assessed by the ROTEM viscoelastic test. | During surgery (day 0) (before transfusion then at 10min, 1 hour, 3 hours, 6 hours, 9 hours, 12 hours after transfusion) then at day 1 and day 2. | Measurement of blood samples using the ROTEM viscoelastic test |
| Secondary | Characterize the sources of variability in response to fibrinogen concentrate administration as assessed by the Quantra viscoelastic test. | During surgery (day 0) (before transfusion then at 10min, 1 hour, 3 hours, 6 hours, 9 hours, 12 hours after transfusion) then at day 1 and day 2. | measurement of blood samples using the Quantra viscoelastic test |
| Secondary | Characterize the correlation between fibrinogen exposure and postoperative bleeding after fibrinogen administration. | During surgery (day 0) then at day 1 and day 2. | Blood loss in ml measured via surgical drains |
| Secondary | Study the relationship between different estimators of fibrinogen concentration. | through study completion, an average of 7 days | Correlation coefficient between the different estimators of fibrinogen concentration and description using a Bland-Altman plot. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07425600
GET https://conductscience.org/api/trials/v1/NCT07425600/registered