Trial · NCT07432373
Intrapleural Alteplase-Tyloxapol vs Intrapleural Alteplase-DNase in Pleural Infection
NCT07432373, Recruiting, National University of Malaysia
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Intrapleural Alteplase-Tyloxapol vs Intrapleural Alteplase-DNase in Pleural Infection. Trials, record NCT07432373. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07432373
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Intrapleural Alteplase-Tyloxapol vs Intrapleural Alteplase-DNase in Pleural Infection
- NCT number
- NCT07432373
- Status
- Recruiting
- Enrollment
- 80 participants, estimated
- Lead sponsor
- National University of Malaysia
- Conditions
- Pleural Infection
- Interventions
- Intrapleural t-PA/Dnase arm, t-PA (Alteplase) 5-10mg and Tyloxapol 200mg
- First posted
- 2026-02-25
- Last updated
- 2026-06-30
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | To measure the change in the area of pleural opacity in chest x-ray compared to baseline | Day 7 | measured as the percentage of the ipsilateral hemithorax occupied by effusion. The area of pleural opacity and the area of the ipsilateral hemithorax will be measured digitally by two radiologists using Horos Project Software, v3.2.1 as described previously in Multicentre Intrapleural Sepsis Trial 2 (MIST-2) |
| Secondary | Reduction in the level of serum C-reactive protein (CRP) from Day 1 to Day7 measured in mg/dL | Day 7 | reduction in CRP |
| Secondary | Reduction in the level of stotal white cell count from Day 1 to Day7 measured in 10x9/L | Day 7 | reduction in total white cell count |
| Secondary | to evaluate the volume of pleural effusion drainage (in mls) 72 hours following randomization | 72 hours | The net volume of pleural effusion drained measured after subtracting the medication volume instilled |
| Secondary | Length of hospitalization | throughout admission (up to 30 days) | measured in days |
| Secondary | the need for surgical referral | throughout admission (up to 30 days) | If failed intrapleural therapy (Discretion of treating physician) |
| Secondary | to compare of the adverse effects between t-PA/Dnase and t-PA/Tyloxapol and intrapleural saline irrigation. | Day 7 | adverse effects such as clinical deterioration, chest pain requiring escalation of analgesics, gastrointestinal bleeding, bleeding from chest drain site, intrapleural hemorrhage, hemoptysis, Hemoglobin (Hb) drop \>10% from baseline requiring blood transfusion |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers8
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07432373
GET https://conductscience.org/api/trials/v1/NCT07432373/registered