Trial · NCT07467603
ED50 of Remimazolam for Anesthesia Induction in Frail Elderly Patients
NCT07467603, Not applicable, Completed, The First Hospital of Hebei Medical University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. ED50 of Remimazolam for Anesthesia Induction in Frail Elderly Patients. Trials, record NCT07467603. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07467603
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- ED50 of Remimazolam for Anesthesia Induction in Frail Elderly Patients
- NCT number
- NCT07467603
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 58 participants, actual
- Lead sponsor
- The First Hospital of Hebei Medical University
- Conditions
- Frailty, Anesthesia Induction
- Interventions
- Remimazolam Tosilate, Remimazolam Tosilate
- First posted
- 2026-03-12
- Last updated
- 2026-03-12
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Sedation Success (Loss of Consciousness) | up to 2 minutes | Defined as the achievement of Loss of Consciousness (LOC) confirmed by loss of eyelash reflex, no response to verbal commands, Ramsay Sedation Score ≥ 5, and MOAA/S score \< 1. |
| Secondary | Median Effective Dose (ED50) of Remimazolam | Perioperative/Periprocedural | The ED50 calculated via probit analysis based on the Dixon up-and-down sequential allocation method. |
| Secondary | Changes in Tidal Volume (VT) | Baseline, 30 seconds, 60 seconds, 90 seconds, and up to 120 seconds post-administration | Continuous assessment of spontaneous Tidal Volume (VT) utilizing a non-invasive Respiratory Volume Monitor (RVM) to evaluate subclinical respiratory depression. |
| Secondary | Mean Arterial Pressure (MAP) | Baseline and up to 2 minutes post-administration | Changes in Mean Arterial Pressure (MAP) during the induction period, measured in mmHg. |
| Secondary | Heart Rate (HR) | Baseline and up to 2 minutes post-administration | Changes in Heart Rate (HR) during the induction period, measured in beats per minute. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07467603
GET https://conductscience.org/api/trials/v1/NCT07467603/registered