Trial · NCT07469852
Effects of Caffeine Ingestion on Morning Cognitive and 4-km Time Trial Performance in Males
NCT07469852, Phase 1, Phase 2, Active not recruiting, Liverpool John Moores University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effects of Caffeine Ingestion on Morning Cognitive and 4-km Time Trial Performance in Males. Trials, record NCT07469852. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07469852
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effects of Caffeine Ingestion on Morning Cognitive and 4-km Time Trial Performance in Males
- NCT number
- NCT07469852
- Status
- Active not recruiting
- Phases
- Phase 1, Phase 2
- Enrollment
- 15 participants, estimated
- Lead sponsor
- Liverpool John Moores University
- Conditions
- Caffeine, Placebo - Control, No Pill
- Interventions
- Caffeine (300 mg), Placebo, No Pill
- First posted
- 2026-03-13
- Last updated
- 2026-03-13
Source ClinicalTrials.gov
Registered outcomes21
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Morning 4-km time-trial finishing time | From enrolment to last experimental session (~4 weeks) | 4-km cycling time-trial (Watbike Pro, Nottingham UK) finishing time in minute and seconds. \~ 4-6 minutes. |
| Primary | 4-km cycling time-trial split times every 1 km. | From familiarisation to the final experimental session (~4 weeks) | 4-km cycling time-trial (Watbike Pro, Nottingham UK) split times (in minutes and seconds) every 1 km. |
| Primary | Heart rate every 1-km | From familiarisation to the final experimental session (~4 weeks) | Heart rate measured every 1-km during the 4-km time-trial, using a heart rate monitor. |
| Primary | Rating of perceived exertion every 1-km | From familiarisation to the final experimental session (~4 weeks) | Rating of perceived exertion every 1-km for the 4-km time-trail. Measured on a 6 (no exertion) to 20 (maximal exertion) scale. Takes \~1 s. |
| Primary | Perceived pacing taken at 2 and 4 km | From familiarisation to the final experimental session (~4 weeks) | Perceived pacing taken at 2 and 4 km of the 4-km time trial. The scale is a 10 cm visual analogue scale where -5 represents pacing to slow to complete the 2 km as fast as possible, zero = optimal pacing and +5 went to fast. Takes \~1 s to answer. |
| Primary | Morning Trail Making Test time to completion in seconds (TMT; parts A and B) | From enrolment to last experimental session (4 weeks) | To assess the effect of 300 mg caffeine (CAFF) vs placebo (PLAC) vs no-pill (NoPill) on morning Trail Making Test time to completion in seconds (TMT; parts A and B). In part A the circles are numbered 1-25, and the participant is instructed to draw lines to connect the numbers in ascending order. In part B, the circles include both numbers (1-13) and letters (A-L) and the participant is instructed to draw lines to connect the circles in ascending pattern but with the added task of alternating between numbers and letters (i.e., 1-A-2-B-3-C etc.). In both parts the participant is instructed to connect to the circles as fast as possible, without lifting the pencil from the paper. If an error is made, this is pointed out immediately and the participant is allowed to correct it. During the test, time to completion is measured, with a higher time indicative of the greater impairment. |
| Primary | Morning Rey Auditory Verbal Learning Test | From familiarisation to the final experimental session (~4 weeks) | Rey Auditory Verbal Learning Test: The RAVLT is a neuropsychological assessment designed to evaluate verbal memory. The test is designed as a list-learning paradigm in which the volunteer hears a list of 15 nouns and is asked to recall as many words from the list as possible. The number correct and the number that were given by the participant but not on the list (intrusions) are noted. This process is re-peated 4 more times. The process is repeated but with a second interference list (List B) is presented in the same manner, and the participant is asked to recall as many words as possible from List B and scoring recorded. . After the interference trial, the participant is immediately asked to recall the words from List A, which they heard five times previously and the number of correct words and intrusions are recorded. RAVTL total number, number of dis-tractions and retention are recorded and analysed. |
| Primary | Morning Stroop word-colour interference test | From familiarisation to the final experimental session (~4 weeks) | Stroop word-colour interference test. The participants were asked to read out their responses to words or colours for 45 s as quickly as possible and to leave no errors uncorrected. This was filmed and the number of errors and total amount completed was recorded and analysed. The first sheet had text (red, blue, yellow, black and green) in black ink (naming word test, W). The second sheet had blocks of colour corresponding to the text on the first sheet (naming colour test, C). With the third sheet, the participants had to read out the word (which was coloured differently to the word, e.g., the word was yellow and the colour red, referred to as the naming colour of word test, CW) and for the fourth sheet, the participants had to read out the colon (which was wrongly named, e.g., the colour was yellow but the word was red, referred to as the naming of word not colour test, WC). In this fourth sheet, the words were printed in the reverse order to the third sheet. |
| Secondary | Rectal temperature @rest and after warm-up | From enrolment to last experimental session (4 weeks) | Rectal temperature by a soft flexible rectal probe (mini-thermistor, Grant Instruments, Shepreth, UK) approximately 10 cm beyond the external anal sphincter. Duration in each session no longer than 35 mins. |
| Secondary | Blood lactate @ rest, pre TT and after | From enrolment to last experimental session (4 weeks) | Blood lactate (finger tip) values will betaken @ rest, pre TT and after |
1 to 10 of 21Source ClinicalTrials.gov
See all 21 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers4
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests3
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Trail Making Test A | Primary outcome | ConductCognition |
| Trail Making Test B | Primary outcome | ConductCognition |
| Verbal Learning | Primary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07469852
GET https://conductscience.org/api/trials/v1/NCT07469852/registered?page=2