The Role of Environmental Temperatures in Respiratory Control
NCT07470086, Not applicable, Not yet recruiting, Indiana University
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | The Role of Environmental Temperatures in Respiratory Control | ClinicalTrials.gov |
| NCT number | NCT07470086 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 15 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Indiana University | ClinicalTrials.gov |
| Conditions | Work of Breathing | ClinicalTrials.gov |
| Interventions | Thermoneutral temperature environment, Cold temperature environment, Hot temperature environment | ClinicalTrials.gov |
| First posted | 2026-03-13 | ClinicalTrials.gov |
| Last updated | 2026-03-13 | ClinicalTrials.gov |
Registered outcomes 12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in Stroop Color-Word Test Time Performance | Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration) | Time performance on the Stroop Color-Word Test (min:sec) will be measured every 45 minutes during each experimental breathing task. | ClinicalTrials.gov |
| Primary | Change in Stroop Color-Word Test Error Performance | Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration) | The number of errors on the Stroop Color-Word Test will be measured every 45 minutes each experimental breathing task. | ClinicalTrials.gov |
| Primary | Change in Perception of Dyspnea Intensity | Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration) | Participants will rate perception of dyspnea (breathing) intensity on a visual analog scale (VAS) every 45 minutes during each breathing task. The participant will draw a vertical marker line on a horizontal line (100mm), indicating their breathing perception from "not noticeable" (0mm) to "maximal imaginable intensity" (100mm). | ClinicalTrials.gov |
| Primary | Change in Perception of Dyspnea Unpleasantness | Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration) | Participants will rate perception of dyspnea (breathing) unpleasantness on a visual analog scale (VAS) every 45 minutes during each breathing task. The participant will draw a vertical marker line on a horizontal line(100mm), indicating their breathing perception from "not unpleasant"(0mm) to "maximal imaginable unpleasantness" (100mm). | ClinicalTrials.gov |
| Secondary | Change in Diaphragm Thickness | Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration) | Diaphragm thickness will be measured via Doppler ultrasound of the10th/11th rib space during functional residual capacity (FRC; rest) and end-inspiration, as well as during the maximal inspiratory pressure (MIP)test from FRC before and after each condition. | ClinicalTrials.gov |
| Secondary | Change in Heart Rate Variability | Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration) | Heart rate variability (beats per minute) will be measured continuously during each breathing task via 3-lead electrocardiograph (ECG). | ClinicalTrials.gov |
| Secondary | Change in Peripheral Oxygen Saturation | Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration) | Peripheral oxygen saturation will be measured continuously during each breathing task via pulse oximetry. | ClinicalTrials.gov |
| Secondary | Change in Blood Pressure - Brachial Artery | Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration) | Blood pressure will be measured every 10 minutes during each breathing task via a standard blood pressure cuff and auscultation of the brachial artery. | ClinicalTrials.gov |
| Secondary | Change in Blood Pressure - Finger Photoplethysmography | Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration) | Blood pressure will be measured continuously during each breathing task via finger photoplethysmography. | ClinicalTrials.gov |
| Secondary | Change in Heart Rate | Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration) | Heart Rate will be measured continuously during each breathing task by 3-lead electrocardiograph (ECG). | ClinicalTrials.gov |
| Secondary | Change in Cerebral Blood Oxygen Kinetics | Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration) | Oxyhemoglobin and deoxyhemoglobin (uptake/extraction, uM) will be measured continuously via near-infrared spectroscopy (NIRS) of the pre-frontal cortex during each breathing task. | ClinicalTrials.gov |
| Secondary | Change in Cerebral Blood Velocity | Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration) | Bilateral transcranial Doppler Ultrasound will be used to continuously measure middle and posterior cerebral artery blood velocity during each breathing task. The ultrasound transducers will be placed on both sides of the head at the temporal windows and the positions will be fixed using a transducer holder. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 1
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)