Biology-Driven Cognitive Profiling in Huntington's Disease
NCT07503743, Active not recruiting, Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Trial 8
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Biology-Driven Cognitive Profiling in Huntington's Disease | ClinicalTrials.gov |
| NCT number | NCT07503743 | ClinicalTrials.gov |
| Status | Active not recruiting | ClinicalTrials.gov |
| Enrollment | 90 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | ClinicalTrials.gov |
| Conditions | Huntington's Disease (HD) | ClinicalTrials.gov |
| First posted | 2026-03-31 | ClinicalTrials.gov |
| Last updated | 2026-03-31 | ClinicalTrials.gov |
Registered outcomes 8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Regional Tau PET Binding (SUVR) Using 18F-PI-2620 | Day 1 | Standardized uptake value ratios (SUVR) derived from 18F-PI-2620 PET imaging will be calculated to quantify regional tau tracer uptake in predefined cortical and subcortical brain regions. SUVR values will be computed using the cerebellum as the reference region. | ClinicalTrials.gov |
| Secondary | Cortical Thickness Measured by Structural MRI | Day 1 | Mean cortical thickness (millimeters) derived from 3T structural MRI and processed using automated segmentation software (FreeSurfer). | ClinicalTrials.gov |
| Secondary | Subcortical Volume Measured by Structural MRI | Day 1 | Regional subcortical brain volumes (mm³) derived from 3T structural MRI and processed using automated segmentation software (FreeSurfer). | ClinicalTrials.gov |
| Secondary | Plasma Neurofilament Light Chain (NfL) | Within 15 days of PET imaging | Concentration of neurofilament light chain measured in plasma samples using immunoassay methods in pg/ml. | ClinicalTrials.gov |
| Secondary | Plasma Total Tau | Within 15 days of PET imaging | Concentration of phosphorylated tau protein measured in plasma samples using immunoassay methods in pg/ml | ClinicalTrials.gov |
| Secondary | Plasma Phosphorylated Tau | Within 15 days of PET imaging | Concentration of phosphorylated tau protein measured in plasma samples using immunoassay methods in pg/ml | ClinicalTrials.gov |
| Secondary | Composite Score of Experimental Cognitive Tasks Targeting Early Huntington's Disease Cognitive Changes | Within 15 days of PET imaging | Composite cognitive performance score derived from a set of experimental tasks designed to assess cognitive domains affected early in Huntington's disease, including attentional selection, sensory integration, visuospatial processing, temporal prediction, and cognitive control. | ClinicalTrials.gov |
| Secondary | Global Cognitive Performance Measured by Standard Neuropsychological Tests | Within 15 days of PET imaging | Scores obtained from standardized neuropsychological tests including: * Symbol Digit Modalities Test (SDMT) - processing speed * Stroop Color and Word Test - executive function and cognitive control * Trail Making Test Parts A and B - processing speed and cognitive flexibility * Verbal Fluency Test (phonemic and semantic) - executive function and language | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 42366274 | DERIVED | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)