Trial · NCT07523048
Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder
NCT07523048, Phase 2, Recruiting, Roger McIntyre
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder. Trials, record NCT07523048. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07523048
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder
- NCT number
- NCT07523048
- Status
- Recruiting
- Phases
- Phase 2
- Enrollment
- 30 participants, estimated
- Lead sponsor
- Roger McIntyre
- Conditions
- Major Depressive Disorder (MDD)
- Interventions
- Dextromethorphan-Bupropion
- First posted
- 2026-04-13
- Last updated
- 2026-04-13
Source ClinicalTrials.gov
Registered outcomes25
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Striatal BOLD Signal During Reward Processing | Baseline (Day 1) to endpoint (Day 14) | Change from baseline (Day 1) to endpoint (Day 14) in task-evoked blood oxygen level-dependent (BOLD) signal within striatal regions of interest during the Effort Expenditure for Rewards Task (EEfRT), as measured by functional magnetic resonance imaging (fMRI). |
| Secondary | Change in Effort-Based Decision-Making During Reward Task | Baseline (Day 1) to endpoint (Day 14) | Change from baseline (Day 1) to endpoint (Day 14) in effort-based decision-making as measured by the proportion of hard-task choices selected during the Effort Expenditure for Rewards Task (EEfRT), with higher values indicating greater willingness to exert effort for reward. |
| Secondary | Change in Anhedonia as Measured by the Snaith-Hamilton Pleasure Scale (SHAPS) | Baseline (Day 1) to endpoint (Day 14). | Change from baseline (Day 1) to endpoint (Day 14) in anhedonia severity as measured by the Snaith-Hamilton Pleasure Scale (SHAPS), a 14-item self-report scale in which each item is rated on a 4-point Likert scale (1 = strongly agree to 4 = strongly disagree). Total scores range from 14 to 56, with higher scores indicating greater anhedonia. |
| Secondary | Change in Anhedonia as Measured by the Dimensional Anhedonia Rating Scale (DARS) | Baseline (Day 1) to endpoint (Day 14) | Change from baseline (Day 1) to endpoint (Day 14) in anhedonia severity as measured by the Dimensional Anhedonia Rating Scale (DARS), a self-report scale assessing interest and pleasure across multiple domains, with scores ranging from 0 to 68, where higher scores indicate greater hedonic capacity (i.e., lower anhedonia). |
| Secondary | Change in Anhedonia as Measured by the Montgomery-Åsberg Depression Rating Scale - Anhedonia Factor (MADRS-AF) | Baseline (Day 1) to endpoint (Day 14) | Change from baseline (Day 1) to endpoint (Day 14) in anhedonia severity as measured by the Montgomery-Åsberg Depression Rating Scale - Anhedonia Factor (MADRS-AF), a clinician-rated subscale derived from the MADRS consisting of 5 items, each scored from 0 to 6, with total scores on this subscale ranging from 0 to 30, where higher scores indicate greater anhedonia. |
| Secondary | Change in Processing Speed as Measured by Trail Making Test Part A (TMT-A) | Baseline (Day 1) to endpoint (Day 14) | Change from baseline (Day 1) to endpoint (Day 14) in processing speed as measured by completion time on the Trail Making Test Part A (TMT-A), where shorter completion times (in seconds) indicate better performance. |
| Secondary | Change in Executive Function as Measured by Trail Making Test Part B (TMT-B) | Baseline (Day 1) to endpoint (Day 14) | Change from baseline (Day 1) to endpoint (Day 14) in executive function as measured by completion time on the Trail Making Test Part B (TMT-B), where shorter completion times (in seconds) indicate better performance. |
| Secondary | Change in Processing Speed as Measured by the Wechsler Adult Intelligence Scale (WAIS) Symbol Search Subtest | Baseline (Day 1) to endpoint (Day 14) | Change from baseline (Day 1) to endpoint (Day 14) in processing speed as measured by the Symbol Search subtest of the Wechsler Adult Intelligence Scale (WAIS), a timed task in which participants identify target symbols within a fixed time period. Scores reflect the number of correct responses achieved within 2 minutes, with total scores ranging from 0 to 60, and higher scores indicating better performance. |
| Secondary | Change in Cognitive Performance as Measured by the Digit Symbol Substitution Test (DSST) | Baseline (Day 1) to endpoint (Day 14) | Change from baseline (Day 1) to endpoint (Day 14) in cognitive performance as measured by the Digit Symbol Substitution Test (DSST), a timed test of processing speed in which participants match symbols to numbers according to a key. Raw scores reflect the number of correct symbol-digit pairings completed within a fixed time period (120 seconds), with higher scores indicating better performance. |
| Secondary | Change in Depressive Symptom Severity as Measured by the Montgomery-Åsberg Depression Rating Scale (MADRS) | Baseline (Day 1) to endpoint (Day 14) | Change from baseline (Day 1) to endpoint (Day 14) in depressive symptom severity as measured by the Montgomery-Åsberg Depression Rating Scale (MADRS), a clinician-rated scale with total scores ranging from 0 to 60, where higher scores indicate greater depression severity. |
1 to 10 of 25Source ClinicalTrials.gov
See all 25 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests7
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Effort for Rewards Task | Primary outcome | ConductCognition |
| Effort Discounting Task | Secondary outcome | ConductCognition |
| Implicit Association Test (IAT) | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
| Symbol Scan Task | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07523048
GET https://conductscience.org/api/trials/v1/NCT07523048/registered?page=2