Trial · NCT07532460
The Role of Potassium Channels in Working Memory Impairments of Chronic Cocaine Users
NCT07532460, Not applicable, Recruiting, Boris Quednow
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Role of Potassium Channels in Working Memory Impairments of Chronic Cocaine Users. Trials, record NCT07532460. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07532460
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Role of Potassium Channels in Working Memory Impairments of Chronic Cocaine Users
- NCT number
- NCT07532460
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 40 participants, estimated
- Lead sponsor
- Boris Quednow
- Conditions
- Cocaine Use Disorder (CUD), Cognitive Impairments
- Interventions
- 4-aminopyridine (4-AP), Placebo
- First posted
- 2026-04-16
- Last updated
- 2026-08-17
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Global Working Memory Performance | Baseline and during both experimental sessions | Working memory performance will be assessed using a cognitive test battery covering different domains of working memory, including visuo-spatial (Spatial Working Memory \[SWM\], total errors; Paired Associates Learning \[PAL\], first trial memory score) and verbal-numeric components (Letter Number Sequencing Task \[LNST\], total score; Letter N-Back Task, discrimination index d'). Individual test scores will be standardized (z-transformation) and combined into a global working memory score according to Vonmoos et al (2013). |
| Secondary | Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) | Baseline and during both experimental sessions | Neurofilament light chain (NfL), a marker of axonal integrity, and glial fibrillary acidic protein (GFAP), a marker of microglia activation, levels will be analysed to assess potential drug challenge-related brain structural remodelling or to predict the effect of potassium challenge blockade. |
| Secondary | Subjective ratings of current mood and craving | Baseline and during both experimental sessions | Subjective ratings of current mood (affective state, stress) and craving, pre- and post-cue exposure. Current affective state will be assessed using the Positive and Negative Affect Schedule (PANAS; positive affect range: 10-50, negative affect range: 10-50) and visual analog scales (VAS; range 0-100, with higher scores indicating greater levels) of affective state and stress burden. Current cocaine craving will be assessed using the Cocaine Craving Questionnaire-Brief (CCQ-Brief; total score range: 10-70, with higher scores representing worse outcomes) and visual analog scales (VAS; range 0-100, with higher scores indicating greater levels) of craving intensity, distinguishing between wanting, needing and having the urge for cocaine. |
| Secondary | Adverse effects of the study drug | During both experimental sessions | Potential adverse effects of the study drug will be assessed using the List of Complaints and visual analog scales (VAS; range 0-100, with higher scores indicating greater levels) of perceived effects of the substance, dizziness, drowsiness, nausea and impaired concentration. |
| Secondary | Plasma concentration | During both experimental sessions | Plasma concentration of the study drug |
| Secondary | Heart rate variability | During both experimental sessions | Heart rate variability is recorded during the test sessions to measure the level of stress and to investigate whether the physiological strain of the test is reduced when taking the study drug. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests4
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| 1-Back Task | Primary outcome | ConductCognition |
| 2-Back Task | Primary outcome | ConductCognition |
| Letter-Number Sequencing Task | Primary outcome | ConductCognition |
| Paired Associate Learning | Primary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07532460
GET https://conductscience.org/api/trials/v1/NCT07532460/registered