Trial · NCT07536022
At-home taVNS for Neurorehabilitation in Parkinson's Disease
NCT07536022, Not applicable, Recruiting, Medical University of South Carolina
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. At-home taVNS for Neurorehabilitation in Parkinson's Disease. Trials, record NCT07536022. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07536022
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- At-home taVNS for Neurorehabilitation in Parkinson's Disease
- NCT number
- NCT07536022
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 16 participants, estimated
- Lead sponsor
- Medical University of South Carolina
- Conditions
- Parkinson's Disease
- Interventions
- transcutaneous auricular nerve stimulation
- First posted
- 2026-04-17
- Last updated
- 2026-06-15
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Adherence to At-Home Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) | Baseline to end of 8-week at-home taVNS intervention | Adherence defined as the percentage of prescribed daily taVNS sessions completed over the 8-week intervention period, measured using automated device usage logs from the Sparrow Link Hub and mobile application. |
| Primary | Change in Parkinson's Disease Motor Symptoms Assessed by the Movement Disorder Society-Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS III) | Baseline, Week 4, and Week 8 | Change in motor symptom severity measured using the MDS-UPDRS Part III. Total score range: 0-132, with higher scores indicating worse motor impairment |
| Secondary | Change in Spatiotemporal Gait Parameters | Baseline, Week 4, Week 8, and 1-month follow-up | Change in fear of falling measured using the FES-I questionnaire. Total score range: 16-64, with higher scores indicating greater concern about falling. |
| Other | Target Engagement Measured by Resting-State Functional Connectivity MRI | Baseline and Week 8 | Change in resting-state functional connectivity between locomotor, cognitive, and limbic networks measured using resting-state functional MRI. Connectivity metrics will be derived from seed-based analyses to assess changes in inter-network and intra-network connectivity. |
| Other | Change in Global Severity and Improvement Assessed by the Clinical Global Impression Scales (CGI-S and CGI-I) | Baseline, Week 4, and Week 8 | Change in clinician-rated global illness severity (CGI-S) and global improvement (CGI-I). CGI-S score range: 1 (Normal) to 7 (Among the most extremely ill). CGI-I score range: 1 (Very much improved) to 7 (Very much worse). |
| Other | Change in Freezing of Gait Assessed by the New Freezing of Gait Questionnaire (nFOG-Q) | Baseline, Week 4, Week 8, and 1-month follow-up | Change in freezing of gait severity measured by the nFOG-Q. Total score range: 0-28, with higher scores indicating more severe freezing of gait. |
| Other | Change in Non-Motor Symptoms Assessed by the Movement Disorder Society Non-Motor Symptoms Scale (MDS-NMS) | Baseline, Week 4, Week 8, and 1-month follow-up | Change in non-motor symptom burden measured using the MDS-NMS. Higher scores indicate greater non-motor symptom severity |
| Other | Change in Cognitive Function Assessed by Neuropsychological Testing | Baseline, Week 4, and Week 8 | Change in cognitive performance assessed using standardized neuropsychological tests including the Delis-Kaplan Executive Function System (verbal fluency and switching), Stroop Color-Word Interference Test, Digit Span, and FAS Verbal Fluency Test. Higher test scores indicate better cognitive performance. |
| Other | Change in Anxiety Symptoms Assessed by the Hamilton Anxiety Rating Scale (HAM-A) | Baseline, Week 4, and Week 8 | Change in anxiety severity measured by the HAM-A. Score range: 0-56, with higher scores indicating greater anxiety severity. |
| Other | Change in Depressive Symptoms Assessed by the Hamilton Depression Rating Scale (HAM-D) | Baseline, Week 4, and Week 8 | Change in depressive symptom severity measured by the HAM-D. Higher scores indicate greater depressive symptom severity. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests3
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Digit Span Test | Other outcome | ConductCognition |
| Stroop Color-Word Test | Other outcome | ConductCognition |
| Verbal Fluency | Other outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07536022
GET https://conductscience.org/api/trials/v1/NCT07536022/registered